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Table 3 Weight change and subsequent cancer risk: subjects stratified by their age at diagnosis of cancer

From: Changes in body weight and the risk of breast cancer in BRCA1 and BRCA2mutation carriers

Weight change between age 18 and 30 years Cases (number) Controls (number) ORa (95% CI) P P for trend
In all subjectsb 966 966    
Loss of at least 10 pounds 53 81 0.66 (0.46–0.93) 0.03  
Loss of <10 to gain of ≤ 10 pounds 536 542 1 (referent)   
Gain of 10 to ≤ 20 pounds 227 190 1.19 (0.96–1.49) 0.12  
Gain of > 20 pounds 150 135 1.00 (0.77–1.30) 0.99 0.46
According to case subjects' age at diagnosis      
   >30 to ≤ 40 yearsc 478 478    
Loss of at least 10 pounds 23 49 0.47 (0.28–0.79) 0.005  
Loss of <10 to gain of ≤ 10 poundsd 255 254 1 (referent)   
Gain of 10 to ≤ 20 pounds 112 89 1.25 (0.91–1.71) 0.17  
Gain of >20 pounds 88 86 1.03 (0.72–1.47) 0.88 0.48
   >40 yearsd 488 488    
Loss of at least 10 pounds 30 32 0.97 (0.52–1.65) 0.91  
Loss of <10 to gain of ≤ 10 poundsd 281 288 1 (referent)   
Gain of 10 to ≤ 20 pounds 115 101 1.16 (0.85–1.59) 0.36  
Gain of >20 pounds 62 67 0.95 (0.64–1.43) 0.82 0.75
  1. Subjects were women with a deleterious mutation in BRCA1 or BRCA2 who did (case subjects) or did not (control subjects) receive a diagnosis of cancer. aAll odds ratios (ORs) were derived using univariate conditional logistic regression. bExcludes case subjects diagnosed at age ≤ 30 years. cExcludes case subjects diagnosed at age ≤ 30 and >40 years. dExcludes case subjects diagnosed at ≤ 40 years. CI, confidence interval.