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Table 2 Anthropometric variables in women with a deleterious BRCA1 or BRCA2 mutationa

From: Changes in body weight and the risk of breast cancer in BRCA1 and BRCA2mutation carriers

  All Premenopausal Postmenopausal
Variable Cases n = 1073 Controls n = 1073 P Cases n = 817 Controls n = 817 P Cases n = 256 Controls n = 256 P
Weight (pounds)          
   At birth 7.1 (1.3) 7.1 (1.3) 0.67 NA NA NA NA NA NA
   At age 18 120.6 (17.2) 122.3 (19.1) 0.03 121.5 (17.1) 122.9 (19.2) 0.11 117.8 (17.3) 120.4 (18.5) 0.10
   At age 30c 130.9 (17.3) 131.2 (18.5) 0.75 131.9 (17.1) 132.2 (18.5) 0.87 127.9 (17.4) 128.6 (18.6) 0.69
   At age 40d 137.7 (23.4) 137.7 (24.3) 0.99 139.7 (22.8) 138.7 (25.0) 0.63 135.3 (23.9) 136.5 (23.4) 0.59
Current height (inches) 64.2 (2.6) 64.3 (2.6) 0.44 64.3 (2.6) 64.5 ± 2.6 0.50 63.9 ± 2.7 63.7 ± 2.7 0.10
Body mass indexb          
   At age 18 (kg/m2) 20.57 (2.8) 20.77 (3.0) 0.10 20.65 (2.8) 20.74 (3.0) 0.52 20.31 (2.7) 20.88 (2.9) 0.03
   At age 30 (kg/m2)c 22.35 (3.4) 22.32 (3.7) 0.88 22.44 (3.4) 22.33 (3.9) 0.56 22.08 (3.4) 22.31 (3.1) 0.43
   At age 40 (kg/m2)d 23.77 (3.9) 23.73 (3.9) 0.88 24.06 (3.8) 23.67 (4.1) 0.26 23.42 (4.0) 23.80 (3.7) 0.29
Weight gain (pounds)          
   From age 18 to 30c 10.5 (15.2) 9.4 (17.0) 0.14 10.6 (15.1) 9.8 (18.2) 0.35 10.1 (15.7) 8.2 (13.0) 0.23
   From age 30 to 40d 9.4 (12.5) 9.2 (13.3) 0.82 10.6 (12.5) 9.1 (15.3) 0.23 7.9 (12.3) 8.2 (10.5) 0.23
   From age 18 to 40d 18.6 (19.5) 18.1 (20.4) 0.71 19.9 (20.2) 19.0 (22.1) 0.61 17.0 (18.6) 17.1 (18.2) 0.98
  1. The subjects were women who did (case subjects) or did not (control subjects) have a diagnosis of invasive breast cancer. aP values are univariate and were derived using Student's t-test and include both BRCA1 and BRCA2 mutation carriers. Other values are means (standard deviations). bExcludes subjects with missing data on current height. cCalculated for pairs in which case subjects were diagnosed at age >30 years. dCalculated for pairs in which case subjects were diagnosed at age >40 years. NA, not applicable.