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Table 1 Likelihood ratios for the S384F variant

From: Strong evidence that the common variant S384F in BRCA2has no pathogenic relevance in hereditary breast cancer

 

LR for S384F (BRCA2)

Co-segregation

3.236

Co-occurrence

0.00000111

Loss of heterozygosity

0.00391

Overall LR

1.4 × 10-8

  1. An overall likelihood ratio (LR) of <0.01 is considered to prove that the variant is neutral [3].
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Breast Cancer Research

ISSN: 1465-542X

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