Phosphorylation of estrogen receptor α serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer

Table 2 Correlations between immunohistochemistry scores for expression and phosphorylation of hormone receptors in primary breast tumors

Receptor	ER-α (1D5)	ER-α Ser118	ER-α Ser167	ER-β1	ER-βcx/β2	PR (636)	PRA
ER-α Ser118	+0.224^a
	0.055^b
ER-α Ser167	+0.140	+0.556
	0.23	<0.0001*
ER-β1	+0.039	+0.589	+0.417
	0.74	<0.0001*	0.0003*
ER-βcx/β2	+0.009	+0.640	+0.518	+0.693
	0.94	<0.0001*	<0.0001*	<0.0001*
PR (636)	+0.446	+0.032	+0.011	+0.004	-0.015
	0.0001*	0.78	0.92	0.97	0.90
PRA	+0.256	+0.463	+0.394	+0.203	+0.378	+0.500
	0.028*	<0.0001*	0.0007*	0.081	0.0011*	<0.0001*
PRB	+0.187	+0.211	+0.149	+0.206	+0.325	+0.553	+0.526
	0.11	0.070	0.20	0.077	0.0052*	<0.0001*	<0.0001*

^aSpearman correlation coefficient; ^bP, Spearman rank correlation test. * P <0.05.
ER, estrogen receptor; PR(A,B), progresterone receptor (A,B).

ISSN: 1465-542X