Skip to main content

Table 2 MBD2 genotypes, menopausal status and breast cancer risk in Caucasians

From: Genotypes and haplotypes of the methyl-CpG-binding domain 2 modify breast cancer risk dependent upon menopausal status

MBD2 genotype

Cases (n = 393)

Controls (n = 436)

Crude OR (95% CI)

ORa (95% CI)

SNP 1 (rs1259938)

All women

   G/G

210 (53.4)

226 (51.8)

1.00

1.00

   G/A

158 (40.2)

179 (41.1)

0.95 (0.71–1.27)

0.94 (0.70–1.26)

   A/A

25 (6.4)

31 (7.1)

0.86 (0.49–1.52)

0.86 (0.49–1.54)

   G/A + A/A

183 (46.6)

210 (48.2)

0.94 (0.71–1.23)

0.94 (0.71–1.24)

Premenopausal women

   G/G

59 (67.1)

69 (47.3)

1.00

1.00

   G/A

25 (28.4)

65 (44.5)

0.43 (0.24–0.77)

0.40 (0.22–0.74)

   A/A

4 (4.6)

12 (8.2)

0.39 (0.12–1.26)

0.39 (0.12–1.29)

   G/A + A/A

29 (33.0)

77 (52.7)

0.42 (0.24–0.73)

0.41 (0.23–0.72)

Postmenopausal women

   G/G

151 (49.5)

157 (54.1)

1.00

1.00

   G/A

133 (43.6)

114 (39.3)

1.24 (0.88–1.74)

1.24 (0.88–1.75)

   A/A

21 (6.9)

19 (6.6)

1.16 (0.59–2.27)

1.15 (0.58–2.29)

   G/A + A/A

154 (50.5)

134 (45.9)

1.23 (0.90–1.70)

1.24 (0.90–1.72)

SNP 2 (rs609791)

All women

   C/C

243 (63.9)

260 (61.6)

1.00

1.00

   C/G

120 (31.6)

140 (33.2)

0.92 (0.68–1.24)

0.92 (0.68–1.24)

   G/G

17 (4.5)

22 (5.2)

0.83 (0.43–1.59)

0.85 (0.44–1.64)

   C/G + G/G

237 (36.1)

162 (38.4)

0.90 (0.68–1.21)

0.91 (0.68–1.22)

Premenopausal women

   C/C

60 (70.6)

80 (56.3)

1.00

1.00

   C/G

20 (23.5)

55 (38.7)

0.48 (0.26–0.89)

0.47 (0.26–0.88)

   G/G

5 (5.9)

7 (5.0)

0.95 (0.29–3.15)

1.02 (0.30–3.49)

   C/G + G/G

25 (29.4)

62 (43.7)

0.54 (0.30–0.95)

0.54 (0.30–0.96)

Postmenopausal women

   C/C

183 (62.0)

180 (64.3)

1.00

1.00

   C/G

100 (33.9)

85 (30.4)

1.16 (0.81–1.65)

1.15 (0.80–1.64)

   G/G

12 (4.1)

15 (5.3)

0.79 (0.36–1.73)

0.80 (0.36–1.76)

   C/G + G/G

112 (38.0)

100 (35.7)

1.10 (0.78–1.55)

1.10 (0.78–1.55)

  1. Values are expressed as n (%). aAdjusted for age (as a continuous variable), body mass index (<25 kg/m2, 25–29.99 kg/m2, >29.99 kg/m2), family history of breast cancer in first-degree relatives, menopausal status, family income (tertiles based on distribution of controls), lifetime months of breast feeding (never, 1–5, 6–15, ≥ 15 months) and study site. CI, confidence interval; OR, odds ratio.