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Table 1 Combination index values induced by sequential treatments

From: Addition of 5-fluorouracil to doxorubicin-paclitaxel sequence increases caspase-dependent apoptosis in breast cancer cell lines

   MCF-7 BRC-230
   CI value at inhibition of CI value at inhibition of
Drug combination Combination ratio 75% 90% 95% 75% 90% 95%
Dox→Pacl 1:1 0.3 0.3 0.4 0.1 0.2 0.2
Dox→Pacl→48-h washout→5-FU 1:1:10 0.0005 0.002 0.005 0.002 0.007 0.02
  1. 5-FU, 5-fluorouracil; CI, combination index; Dox, doxorubicin; Pacl, paclitaxel.