Table 3 Pharmacokinetics of scFv(FRP5)-ETA
Dose level (μg/kg) | Peak concentration range (ng/ml) | Peak concentration mean (ng/ml) | AUC (ng* hour/ml) | Plasma clearance (l/hour) | Half-life (hours) |
|---|---|---|---|---|---|
2 | n.d. | n.d. | n.d. | n.d. | n.d. |
4 | 18–49 | 39 ± 18 | 39 ± 1 | 6.6 ± 0.6 | 0.55 ± 0.02 |
10 | 128–129 | 129 ± 1 | 138 ± 64 | 5.3 ± 2.1 | 0.74 ± 0.27 |
12.5 | 93–204 | 160 ± 35 | 178 ± 100 | 4.9 ± 3.1 | 0.73 ± 0.30 |
20 | 115–307 | 236 ± 105 | 326 ± 146 | 3.8 ± 2.2 | 0.73 ± 0.22 |