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Table 1 Patient characteristics

From: Phase I clinical study of the recombinant antibody toxin scFv(FRP5)-ETA specific for the ErbB2/HER2 receptor in patients with advanced solid malignomas

Patient

Age (years), sex

Cancer type

Stage at diagnosis/surgery

Sites of metastasis

Prior therapy

N01

61, female

Head and neck

T2N2bMX

Local, intrapulmonal, mediastinal

Surgery, radiation, chemotherapy

U01

61, female

Breast

T2N2M1

Liver, bone

Surgery, chemotherapy, herceptin

U02

56, female

Breast

T4N1bM0

Lymph node, liver, central nervous system, skin, bone

Surgery, radiation, chemotherapy, herceptin

U03

68, female

Breast

T3N1M0

Lymph node, bone

Surgery, radiation, chemotherapy, herceptin, hormonal therapy

U04

64, female

Breast

T3N0M0

Local, skin, bone, intrapulmonal

Surgery, chemotherapy, herceptin

U05

71, female

Breast

T1aN3cM1

Lymph node, skin

Surgery, chemotherapy, herceptin

N03

63, female

Breast

T3N1bM0

Liver

Surgery, chemotherapy, herceptin

N04

55, male

Transitional cell carcinoma

TXNXMX

Lymph node

Surgery, chemotherapy, herceptin

N05

72, male

Prostate

T4N3M1

Lymph node, bone, other

Surgery, hormonal therapy

N06

63, male

Prostate

T2bN0M0

Lymph node

Surgery, chemotherapy, hormonal therapy

N07

74, female

Breast

T1N0M0

Liver

Surgery, radiation, hormonal therapy

N09

50, female

Breast

T1N0M0

Lymph node, liver, bone, intrapulmonal, pleural

Surgery, chemotherapy

N10

45, female

Breast

T3bN1bMX

Bone

Surgery, radiation, chemotherapy, herceptin

N12

69, female

Breast

T4N3M1

Local, lymph node, skin

Chemotherapy, hormonal therapy, immunotherapy

N13

46, female

Breast

TXNXMX

Lymph node, liver, central nervous system, skin, bone

Surgery, radiation, chemotherapy, herceptin

N14

82, female

Breast

TXNXMX

Liver, pleural

Surgery, hormonal therapy

N15

70, female

Breast

T2N1MX

Lymph node, skin, bone

Surgery, radiation, chemotherapy, herceptin

N17

62, male

Non small cell lung carcinoma

T2cN2cM1

Lymph node, bone, intrapulmonal

Patient refused standard therapy