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Table 1 Suggested transcriptional targets of BRCA1

From: The pathology of familial breast cancer: The pathology of familial breast cancer How do the functions of BRCA1 and BRCA2 relate to breast tumour pathology?

Gene Regulation Function
p21 WAF1 ↑↓* inhibitor of cyclin dependant kinases
BAX proapoptotic
GADD45 G2/M checkpoint
MDM2 regulation of p53
CDC25A phosphatase/cell cycle regulation
Synthetic estogen  
receptor responsive promoter  
  1. *Overexpression of BRCA1 activatesp21 WAF1 expression [19*,20,21,22]. However, p21 WAF1 is alsoactivated in BRCA1-null mice [29**].