The pathology of familial breast cancer: The pathology of familial breast cancer How do the functions of BRCA1 and BRCA2 relate to breast tumour pathology?

Table 1 Suggested transcriptional targets of BRCA1

Gene	Regulation	Function
p21 ^WAF1	↑↓*	inhibitor of cyclin dependant kinases
BAX	↑	proapoptotic
GADD45	↑	G2/M checkpoint
MDM2	↑	regulation of p53
CDC25A	↓	phosphatase/cell cycle regulation
Synthetic estogen	↓
receptor responsive promoter

^*Overexpression of BRCA1 activatesp21 ^WAF1 expression [19*,20,21,22]. However, p21 ^WAF1 is alsoactivated in BRCA1-null mice [29**].

ISSN: 1465-542X