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Table 4 Combined effect of alcohol and category of benign breast disease histology on breast cancer riska

From: Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case–control study

    

Jointly-classifiedb

Stratifiedc>

Category of BBD

Recent alcohol consumption (g/day)

Cases

Controls

OR (95% CI)d

OR (95% CI)e

OR (95% CI)d

OR (95% CI)e

Nonproliferative

       
 

0

21

178

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

 

<5

27

165

1.41 (0.76–2.60)

1.42 (0.77–2.65)

1.34 (0.72–2.50)

1.46 (0.75–2.85)

 

5–15

14

95

1.27 (0.62–2.62)

1.25 (0.60–2.60)

1.31 (0.63–2.74)

1.15 (0.53–2.53)

 

≥ 15

7

36

1.67 (0.66–4.27)

1.67 (0.65–4.34)

1.85 (0.71–4.84)

1.90 (0.67–5.39)

 

P for trendf

    

0.13

0.20

Proliferative without atypia

      
 

0

46

205

2.04 (1.17–3.57)

1.99 (1.13–3.50)

1.00 (Ref)

1.00 (Ref)

 

<5

52

235

1.91 (1.11–3.29)

1.82 (1.05–3.16)

0.99 (0.63–1.55)

0.99 (0.62–1.56)

 

5–15

34

123

2.43 (1.34–4.41)

2.40 (1.31–4.39)

1.17 (0.70–1.94)

1.14 (0.67–1.91)

 

≥ 15

8

60

1.15 (0.48–2.75)

1.09 (0.45–2.62)

0.59 (0.26–1.33)

0.61 (0.26–1.41)

 

P for trendf

    

0.49

0.58

Proliferative with atypia

      
 

0

23

40

5.57 (2.77–11.21)

5.58 (2.74–11.38)

1.00 (Ref)

1.00 (Ref)

 

<5

30

45

6.65 (3.43–12.90)

6.48 (3.31–12.70)

1.28 (0.62–2.67)

1.29 (0.60–2.78)

 

5–15

14

25

5.35 (2.39–12.01)

5.26 (2.30–12.04)

1.03 (0.42–2.51)

1.02 (0.39–2.68)

 

≥ 15

6

16

3.65 (1.27–10.47)

3.46 (1.19–10.09)

0.66 (0.22–1.97)

0.59 (0.19–1.89)

 

P for trendf

    

0.21

0.17

  1. aNurses' Health Study I (1976 to 1994) and II (1989 to 1995). b Joint classification of BBD category and alcohol consumption where the reference group is women with nonproliferative BBD and 0 alcohol consumption. c The analysis is stratified by type of BBD where the reference group is women with 0 alcohol consumption within each category of BBD. dAdjusted for age at diagnosis, year of biopsy, and follow-up interval. eAdjusted for age at diagnosis, year of biopsy, and follow-up interval, age at menarche, body mass index quartiles, family history of breast cancer, parity/age at first birth, menopausal status/type of menopause, duration of postmenopausal hormone use. fTest for trend based on Wald test for continuous alcohol consumption. BBD, benign breast disease; CI, confidence interval; OR, odds ratio; Ref, reference group for statistical comparisons.