| | | | |
Jointly-classifiedb
|
Stratifiedc>
|
|---|
|
Category of BBD
|
Recent alcohol consumption (g/day)
|
Cases
|
Controls
|
OR (95% CI)d
|
OR (95% CI)e
|
OR (95% CI)d
|
OR (95% CI)e
|
|---|
|
Nonproliferative
| | | | | | | |
| |
0
|
21
|
178
|
1.00 (Ref)
|
1.00 (Ref)
|
1.00 (Ref)
|
1.00 (Ref)
|
| |
<5
|
27
|
165
|
1.41 (0.76–2.60)
|
1.42 (0.77–2.65)
|
1.34 (0.72–2.50)
|
1.46 (0.75–2.85)
|
| |
5–15
|
14
|
95
|
1.27 (0.62–2.62)
|
1.25 (0.60–2.60)
|
1.31 (0.63–2.74)
|
1.15 (0.53–2.53)
|
| |
≥ 15
|
7
|
36
|
1.67 (0.66–4.27)
|
1.67 (0.65–4.34)
|
1.85 (0.71–4.84)
|
1.90 (0.67–5.39)
|
| |
P for trendf
| | | | |
0.13
|
0.20
|
|
Proliferative without atypia
| | | | | | |
| |
0
|
46
|
205
|
2.04 (1.17–3.57)
|
1.99 (1.13–3.50)
|
1.00 (Ref)
|
1.00 (Ref)
|
| |
<5
|
52
|
235
|
1.91 (1.11–3.29)
|
1.82 (1.05–3.16)
|
0.99 (0.63–1.55)
|
0.99 (0.62–1.56)
|
| |
5–15
|
34
|
123
|
2.43 (1.34–4.41)
|
2.40 (1.31–4.39)
|
1.17 (0.70–1.94)
|
1.14 (0.67–1.91)
|
| |
≥ 15
|
8
|
60
|
1.15 (0.48–2.75)
|
1.09 (0.45–2.62)
|
0.59 (0.26–1.33)
|
0.61 (0.26–1.41)
|
| |
P for trendf
| | | | |
0.49
|
0.58
|
|
Proliferative with atypia
| | | | | | |
| |
0
|
23
|
40
|
5.57 (2.77–11.21)
|
5.58 (2.74–11.38)
|
1.00 (Ref)
|
1.00 (Ref)
|
| |
<5
|
30
|
45
|
6.65 (3.43–12.90)
|
6.48 (3.31–12.70)
|
1.28 (0.62–2.67)
|
1.29 (0.60–2.78)
|
| |
5–15
|
14
|
25
|
5.35 (2.39–12.01)
|
5.26 (2.30–12.04)
|
1.03 (0.42–2.51)
|
1.02 (0.39–2.68)
|
| |
≥ 15
|
6
|
16
|
3.65 (1.27–10.47)
|
3.46 (1.19–10.09)
|
0.66 (0.22–1.97)
|
0.59 (0.19–1.89)
|
| |
P for trendf
| | | | |
0.21
|
0.17
|
-
aNurses' Health Study I (1976 to 1994) and II (1989 to 1995). b Joint classification of BBD category and alcohol consumption where the reference group is women with nonproliferative BBD and 0 alcohol consumption. c The analysis is stratified by type of BBD where the reference group is women with 0 alcohol consumption within each category of BBD. dAdjusted for age at diagnosis, year of biopsy, and follow-up interval. eAdjusted for age at diagnosis, year of biopsy, and follow-up interval, age at menarche, body mass index quartiles, family history of breast cancer, parity/age at first birth, menopausal status/type of menopause, duration of postmenopausal hormone use. fTest for trend based on Wald test for continuous alcohol consumption. BBD, benign breast disease; CI, confidence interval; OR, odds ratio; Ref, reference group for statistical comparisons.
