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Table 4 Combined effect of alcohol and category of benign breast disease histology on breast cancer riska

From: Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case–control study

     Jointly-classifiedb Stratifiedc>
Category of BBD Recent alcohol consumption (g/day) Cases Controls OR (95% CI)d OR (95% CI)e OR (95% CI)d OR (95% CI)e
Nonproliferative        
  0 21 178 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
  <5 27 165 1.41 (0.76–2.60) 1.42 (0.77–2.65) 1.34 (0.72–2.50) 1.46 (0.75–2.85)
  5–15 14 95 1.27 (0.62–2.62) 1.25 (0.60–2.60) 1.31 (0.63–2.74) 1.15 (0.53–2.53)
  ≥ 15 7 36 1.67 (0.66–4.27) 1.67 (0.65–4.34) 1.85 (0.71–4.84) 1.90 (0.67–5.39)
  P for trendf      0.13 0.20
Proliferative without atypia       
  0 46 205 2.04 (1.17–3.57) 1.99 (1.13–3.50) 1.00 (Ref) 1.00 (Ref)
  <5 52 235 1.91 (1.11–3.29) 1.82 (1.05–3.16) 0.99 (0.63–1.55) 0.99 (0.62–1.56)
  5–15 34 123 2.43 (1.34–4.41) 2.40 (1.31–4.39) 1.17 (0.70–1.94) 1.14 (0.67–1.91)
  ≥ 15 8 60 1.15 (0.48–2.75) 1.09 (0.45–2.62) 0.59 (0.26–1.33) 0.61 (0.26–1.41)
  P for trendf      0.49 0.58
Proliferative with atypia       
  0 23 40 5.57 (2.77–11.21) 5.58 (2.74–11.38) 1.00 (Ref) 1.00 (Ref)
  <5 30 45 6.65 (3.43–12.90) 6.48 (3.31–12.70) 1.28 (0.62–2.67) 1.29 (0.60–2.78)
  5–15 14 25 5.35 (2.39–12.01) 5.26 (2.30–12.04) 1.03 (0.42–2.51) 1.02 (0.39–2.68)
  ≥ 15 6 16 3.65 (1.27–10.47) 3.46 (1.19–10.09) 0.66 (0.22–1.97) 0.59 (0.19–1.89)
  P for trendf      0.21 0.17
  1. aNurses' Health Study I (1976 to 1994) and II (1989 to 1995). b Joint classification of BBD category and alcohol consumption where the reference group is women with nonproliferative BBD and 0 alcohol consumption. c The analysis is stratified by type of BBD where the reference group is women with 0 alcohol consumption within each category of BBD. dAdjusted for age at diagnosis, year of biopsy, and follow-up interval. eAdjusted for age at diagnosis, year of biopsy, and follow-up interval, age at menarche, body mass index quartiles, family history of breast cancer, parity/age at first birth, menopausal status/type of menopause, duration of postmenopausal hormone use. fTest for trend based on Wald test for continuous alcohol consumption. BBD, benign breast disease; CI, confidence interval; OR, odds ratio; Ref, reference group for statistical comparisons.