Figure 3

Average number (mean ± standard error of the mean) of mammary adenocarcinomas (ADKs) per ADK-bearing rat after daily administration of melatonin (10 mg/kg) for either 15 days before (preventive treatment; open diamonds) or 6 months after (curative treatment; filled diamonds) the administration of dimethylbenz [a]anthracene (DMBA). In both cases, the rats were followed up for 12 months after the administration of DMBA. Hatched bar, duration of preventive treatment; filled bar, duration of curative treatment. *P < 0.05 vs controls; **P < 0.01 vs controls.