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Table 2 Ex vivo detection of metastasis after intracardiac injection (nude mice)

From: Bioluminescent human breast cancer cell lines that permit rapid and sensitive in vivodetection of mammary tumors and multiple metastases in immune deficient mice

 

H2LN (n = 8)

D3H1 (n = 5)

Experimental end-point

Week 5

Week 10

Skeletal metastasis

8/8

4/5

Spine

88%a

60%a

Skull

75%a

40%a

Scapula

75%

40%a

Femur/tibia

63%a

0%a, b

Clavicle

50%

0%

Upper/lower jaw

13–23% ND

0–20%

Ribs and associated tissues

8/8a

4/5a

Brain

7/8a

2/5a

Lungs

6/8a

2/5a

Lymph nodes (axillary/brachial)

5/8a

2/5

Other soft tissues (heart, liver, pancreas, kidney, adrenals, uterus, salivary gland)

4/8

2/5

  1. aMetastasis confirmed by histology in at least one animal sample. bThree out of five mice exhibited in vivo leg signal, and metastasis was confirmed by histology. ND, tissue not analyzed by histology.
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Breast Cancer Research

ISSN: 1465-542X

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