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Table 1 Features of breast tumours according to breast cancer patient's age (years) at diagnosis

From: Relationship of patients' age to histopathological features of breast tumours in BRCA1 and BRCA2and mutation-negative breast cancer families

  BRCA1 tumours BRCA2 tumours Non-BRCA1/2 tumours
  Age <50 Age ≥ 50 P < 0.05a Age <50 Age ≥ 50 P < 0.05a Age <50 Age ≥ 50 P < 0.05a
Histology                
   Ductal cancer 24 (70.6) 13 (76.5)   19 (54.3) 18 (75.0)   34 (58.6) 68 (72.3)  
   Lobular cancer 5 (14.7) 3 (17.6)   12 (34.3) 5 (20.8)   15 (25.9) 15 (16.0)  
   Medullary cancer 5 (14.7)          2 (3.4) 1 (1.1)  
   Other cancers    1 (5.9)   4 (11.4) 1 (4.2)   7 (12.1) 10 (10.6)  
Grade                
   I 1 (3.1) 2 (11.8)   7 (23.3) 5 (22.7)   13 (25.0) 33 (36.7)  
   II 4 (12.5) 7 (41.2)   16 (53.3) 10 (45.5)   30 (57.7) 36 (40.0)  
   III 27 (84.4) 8 (47.1) 0.009 7 (23.3) 7 (31.8)   9 (17.3) 21 (23.3)  
   I to II 5 (16.6) 9 (53.0)   13 (76.7) 15 (68.2)   43 (82.7) 69 (76.7)  
Immunohistochemistry                
   ER- 25 (83.3) 3 (25.0) 0.001 7 (20.6) 10 (52.6) 0.017 17 (29.3) 23 (25.6)  
   ER+ 5 (16.7) 9 (75.0)   27 (79.4) 9 (47.4)   41 (70.7) 67 (74.7)  
   PR- 28 (90.3) 9 (69.2)   12 (35.3) 16 (80.0) 0.001 18 (31.0) 49 (54.4)  
   PR+ 3 (9.7) 4 (30.8)   22 (64.7) 4 (20.0)   40 (69.0) 41 (45.6)  
   p53- 15 (50.0) 12 (92.3) 0.014 27 (81.8) 15 (83.3)   43 (74.1) 75 (81.5)  
   p53+ 15 (50.0) 1 (7.7)   6 (18.2) 3 (16.7)   15 (25.9) 17 (18.5)  
   ERBB2- 23 (76.7) 12 (92.3)   29 (83.3) 16 (84.2)   45 (81.8) 64 (83.1)  
   ERBB2+ 7 (23.3) 1 (7.7)   5 (14.7) 3 (15.8)   10 (18.2) 13 (16.9)  
  1. Values are no. (frequency %). aComparison by age group. There were no significant differences according to patients' age in the non-BRCA1/2 tumours (rightmost column). ER, oestrogen receptor; ERBB2, ERBB2 oncoprotein; PR, progesterone receptor.