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Figure 4 | Breast Cancer Research

Figure 4

From: Mechanisms underlying the growth inhibitory effects of the cyclo-oxygenase-2 inhibitor celecoxib in human breast cancer cells

Figure 4

Celecoxib causes cell cycle arrest in MDA-MB-468 cells. (a,b) Flow cytometric analysis of cells subjected to treatment with vehicle or celecoxib (20–60 μmol/l) for 48 hours. Cells were fixed and permeabilized with 95% ethanol, stained with propidium iodide, and analyzed by flow cytometry. Celecoxib induced growth arrest at the G0/G1 cell cycle checkpoint in MDA-MB-468 cells (panel b) with no cell cycle arrest in the MDA-MB-231 cells (panel a). Mean values for three experiments ± standard deviation of the mean is shown. P values represent significant difference between vehicle control and celecoxib treatment. Experiments were repeated three times, with similar results.

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