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Table 4 Departure from multiplicativity between acetylation status and smoking status among patients with breast cancer

From: A case-only analysis of the interaction between N-acetyltransferase 2 haplotypes and tobacco smoke in breast cancer etiology

 

Acetylation status

   

Smoking

Slow

Fast

OR

Adjusted ORa

Adjusted 95%CI

Nonsmokers

44

24

1.0

1.0

-

Active smokers

Packs (per day)

     

   <1

96

47

1.11

0.97

0.48 to 1.95

   1 to <2

53

33

0.88

0.74

0.35 to 1.60

   ≥ 2

12

2

3.27

1.80

0.33 to 9.81

   Data missing

1

3

   

Duration (years)

     

   <20

39

29

0.73

0.59

0.26 to 1.35

   20 to <40

79

25

1.72

1.32

0.62 to 2.81

   40+

43

30

0.78

0.74

0.33 to 1.63

   Data missing

1

1

   

Duration (years) in relation to first birth

   Nulliparous

41

11

2.03

1.05

0.32 to 3.41

   All before first

11

8

0.75

0.60

0.17 to 2.10

   Before and after first

90

48

1.02

1.03

0.48 to 2.20

   All after first

19

17

0.61

0.52

0.19 to 1.37

   Data missing

1

1

   

Age started (years)

     

   ≤ 13

4

3

0.73

0.63

0.11 to 3.48

   14 to 15

22

7

1.71

1.94

0.61 to 6.19

   16 to 17

35

18

1.06

0.79

0.32 to 1.94

   18 to 21

67

35

1.04

0.94

0.45 to 1.99

   22 to 29

19

11

0.94

0.84

0.31 to 2.30

   ≥ 30

14

10

0.76

0.60

0.21 to 1.71

   Data missing

1

1

   

Quit before diagnosis date (years)

   Current or <5

32

12

1.45

1.25

0.50 to 3.19

   5 to 15

37

19

1.06

0.82

0.35 to 1.95

   >15

71

42

0.92

0.86

0.41 to 1.80

   Data missing

22

12

   

Passive smokers

Duration (years)b

     

   <20

34

18

1.03

0.99

0.43 to 2.33

   20 to <40

48

36

0.73

0.61

0.29 to 1.28

   40+

29

18

0.88

0.81

0.33 to 2.01

   Data missing

3

1

   

Duration (years) in relation to first birth

   Nulliparous

20

14

0.78

0.52

0.16 to 1.69

   All before first

20

8

1.36

1.85

0.59 to 5.83

   Before and after first

56

34

0.90

0.91

0.39 to 2.10

   All after first

6

5

0.65

0.39

0.09 to 1.73

   Data missing

12

12

   

First lived with smoker (age in years)

   <12

51

35

0.84

0.83

0.29 to 2.34

   12 to 20

18

5

3.11

2.43

0.41 to 14.3

   >20

35

28

0.89

0.48

0.17 to 1.42

   Data missing

10

5

   
  1. aControlling for age at diagnosis, alcohol use, BMI, first-degree family history of breast cancer, history of benign breast disease, and parity. bLength of time lived with a smoker. -, not calculated; CI, confidence interval; OR, odds ratio.