TY - JOUR AU - Lash, Timothy L. AU - Bradbury, Brian D. AU - Wilk, Jemma B. AU - Aschengrau, Ann PY - 2005 DA - 2005/03/21 TI - A case-only analysis of the interaction between N-acetyltransferase 2 haplotypes and tobacco smoke in breast cancer etiology JO - Breast Cancer Research SP - R385 VL - 7 IS - 3 AB - N-acetyltransferase 2 is a polymorphic enzyme in humans. Women who possess homozygous polymorphic alleles have a slower rate of metabolic activation of aryl aromatic amines, one of the constituents of tobacco smoke that has been identified as carcinogenic. We hypothesized that women with breast cancer who were slow acetylators would be at increased risk of breast cancer associated with active and passive exposure to tobacco smoke. SN - 1465-542X UR - https://doi.org/10.1186/bcr1013 DO - 10.1186/bcr1013 ID - Lash2005 ER -