Overexpression of β1-chain-containing laminins in capillary basement membranes of human breast cancer and its metastases

Table 3 Summary of laminin-8 and laminin-9 expression in breast tissues as determined by immunohistochemistry

Histological diagnosis	Number of cases	Laminin-8 (n [%])	Laminin-8/9 (n [%])	Laminin-9 (n [%])
Normal breast tissue	14	1 (7)	1 (7)	12 (86)
Ductal carcinoma in situ	5	1 (20)	1 (20)	3 (60)
Invasive ductal carcinoma	16	11 (69)	3 (19)	2 (12)
Metastasis to the brain	3	3 (100)	0	0

The percentage of cases with a given predominant laminin isoform was determined using data in Table 1. For both laminin-8 and laminin-9 expression, the difference between normal tissues and carcinomas or metastases is statistically significant (P < 0.015).

ISSN: 1465-542X