A case-control study of the HER2 Ile655Val polymorphism in relation to risk of invasive breast cancer

Nelson, Stephanie E; Gould, Michael N; Hampton, John M; Trentham-Dietz, Amy

doi:10.1186/bcr1004

Breast Cancer Research

Table 1 Characteristics of invasive breast cancer cases and population controls, Wisconsin, 2001 to 2003

From: A case-control study of the HER2 Ile655Val polymorphism in relation to risk of invasive breast cancer

Characteristic	Cases (N = 1,094)		Controls (N = 976)		OR^†	95% CI^†
	n	%	n	%*
Family history of breast cancer
Absent	855	78.2	829	85.3	1 (Reference)
Present	231	21.1	132	13.1	1.69	1.33–2.16
Unknown	8	0.7	15	1.7	0.44	0.18–1.05
Recent alcohol consumption
None	153	14.0	166	16.8	1 (Reference)
1 drink/week	424	38.8	418	42.5	1.10	0.84–1.45
2–6 drinks/week	385	35.2	270	28.2	1.57	1.19–2.09
7 or more drinks/week	132	12.1	122	12.4	1.23	0.87–1.74
Parity
0–1	262	23.9	217	23.4	1 (Reference)
2	392	35.8	275	29.7	1.22	0.95–1.55
3	253	23.1	209	21.3	0.99	0.76–1.30
4 or more	187	17.1	275	25.6	0.58	0.44–0.77
Menopausal status
Postmenopausal	597	54.6	592	55.1	1 (Reference)
Premenopausal	415	37.9	313	36.8	1.25	0.92–1.70
Unknown	82	7.5	71	8.1	1.06	0.71–1.58
Age at menopause (years)^‡
<45	138	23.1	175	30.1	1 (Reference)
45–49	113	18.9	127	21.4	1.15	0.80–1.65
50–54	205	34.3	172	29.0	1.61	1.16–2.23
55+	68	11.4	65	10.1	1.42	0.91–2.20
Unknown	73	12.2	53	9.4	1.76	1.14–2.77
Body mass index (kg/m²)^‡
<22.6	129	21.6	135	23.1	1 (Reference)
22.6–25.2	144	24.1	136	22.8	1.18	0.82–1.69
25.3–28.9	166	27.8	161	26.8	1.09	0.77–1.54
29.0+	153	25.6	156	26.6	0.97	0.69–1.38
Weight change since age 18 (kg)^‡
Lost 5 or more	14	2.3	20	3.5	0.92	0.42–2.03
Lost 5 to gained 4	95	15.9	109	18.9	1 (Reference)
Gained 5 to 11	148	24.8	140	23.3	1.42	0.97–2.09
Gained 12 to 21	179	30.0	172	28.7	1.30	0.90–1.88
Gained 22 or more	154	25.8	143	24.3	1.32	0.91–1.93
HRT use^‡
Never	184	30.8	233	37.9	1 (Reference)
Former	45	7.5	77	12.6	0.65	0.42–1.01
Current	368	61.6	282	49.4	1.49	1.14–1.95
Age at menarche (years)
< 12	228	20.8	176	18.1	1 (Reference)
12	282	25.8	253	26.4	0.83	0.64–1.09
13	297	27.1	244	24.4	0.94	0.72–1.23
14	183	16.7	172	17.6	0.81	0.61–1.10
15+	98	9.0	119	12.4	0.63	0.45–0.89
Height at age 25 (m)
< 1.60	198	18.1	218	21.9	1 (Reference)
1.60–1.64	295	27.0	263	27.0	1.25	0.96–1.62
1.65–1.67	299	27.3	264	26.9	1.26	0.97–1.64
1.68+	302	27.6	231	24.1	1.47	1.12–1.92

*Control percentages are age-adjusted to the distribution of cases; ^†logistic regression models conditional on age; ^‡among postmenopausal women. CI, confidence interval; HRT, hormone replacement therapy; OR, odds ratio.

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