TY - JOUR AU - Nelson, Stephanie E. AU - Gould, Michael N. AU - Hampton, John M. AU - Trentham-Dietz, Amy PY - 2005 DA - 2005/03/11 TI - A case-control study of the HER2 Ile655Val polymorphism in relation to risk of invasive breast cancer JO - Breast Cancer Research SP - R357 VL - 7 IS - 3 AB - Overexpression of the HER2 proto-oncogene in human cancer cells has been associated with a poor prognosis, and survival improves with therapy targeting the HER2 gene. Animal studies and protein modeling suggest that the Ile655Val polymorphism located in the transmembrane domain of the HER2 protein might influence breast cancer development by altering the efficiency of homodimerization. SN - 1465-542X UR - https://doi.org/10.1186/bcr1004 DO - 10.1186/bcr1004 ID - Nelson2005 ER -