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Table 1 Chemotherapy versus ovarian suppression

From: Endocrinology and hormone therapy in breast cancer: Endocrine therapy in premenopausal women

Study

Treatments

Results

Scottish [6]

CMF versus surgery

No difference

Scandinavian [8]

CMF versus XRT

No difference

ZEBRA [12]

CMF versus OS

No difference for ER+

IBCSG VIII

CMF versus OS

No difference for ER+

GROCTA 02 [47]

CMF versus OS + tamoxifen

No difference

ABCSG 5 [11]

CMF versus OS + tamoxifen

Better RFS for OS + tamoxifen

French

FAC versus OS + tamoxifen

No difference

FASG 06 [48]

FEC versus OS + tamoxifen

No difference

GABG IVA-93 [14]

CMF versus goserelin

No difference

Wallwiener and coworkers [15]

CMF versus leuprolin

No difference

  1. CMF, cyclophosphamide, methotrexate and 5-fluorouracil; ER, oestrogen receptor; FAC, 5-fluorouracil, doxorubicin and cyclophosphamide; FEC, 5-fluorouracil, epirubicin and cyclophosphamide; OS, ovarian suppression; XRT, radiotherapy.