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Table 1 Chemotherapy versus ovarian suppression

From: Endocrinology and hormone therapy in breast cancer: Endocrine therapy in premenopausal women

Study Treatments Results
Scottish [6] CMF versus surgery No difference
Scandinavian [8] CMF versus XRT No difference
ZEBRA [12] CMF versus OS No difference for ER+
IBCSG VIII CMF versus OS No difference for ER+
GROCTA 02 [47] CMF versus OS + tamoxifen No difference
ABCSG 5 [11] CMF versus OS + tamoxifen Better RFS for OS + tamoxifen
French FAC versus OS + tamoxifen No difference
FASG 06 [48] FEC versus OS + tamoxifen No difference
GABG IVA-93 [14] CMF versus goserelin No difference
Wallwiener and coworkers [15] CMF versus leuprolin No difference
  1. CMF, cyclophosphamide, methotrexate and 5-fluorouracil; ER, oestrogen receptor; FAC, 5-fluorouracil, doxorubicin and cyclophosphamide; FEC, 5-fluorouracil, epirubicin and cyclophosphamide; OS, ovarian suppression; XRT, radiotherapy.
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