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  1. Dysregulated Notch signalling contributes to breast cancer development and progression, but validated tools to measure the level of Notch signalling in breast cancer subtypes and in response to systemic therap...

    Authors: Eike-Benjamin Braune, Felix Geist, Xiaojia Tang, Krishna Kalari, Judy Boughey, Liewei Wang, Roberto A. Leon-Ferre, Antonino B. D’Assoro, James N. Ingle, Matthew P. Goetz, Julian Kreis, Kang Wang, Theodoros Foukakis, Anita Seshire, Dirk Wienke and Urban Lendahl
    Citation: Breast Cancer Research 2024 26:4
  2. Previous work in European ancestry populations has shown that adding a polygenic risk score (PRS) to breast cancer risk prediction models based on epidemiologic factors results in better discriminatory perform...

    Authors: Gary R. Zirpoli, Ruth M. Pfeiffer, Kimberly A. Bertrand, Dezheng Huo, Kathryn L. Lunetta and Julie R. Palmer
    Citation: Breast Cancer Research 2024 26:2
  3. Despite radiotherapy ability to significantly improve treatment outcomes and survival in triple-negative breast cancer (TNBC) patients, acquired resistance to radiotherapy poses a serious clinical challenge. P...

    Authors: Jinqiu Tao, Cailin Xue, Meng Cao, Jiahui Ye, Yulu Sun, Hao Chen, Yinan Guan, Wenjie Zhang, Weijie Zhang and Yongzhong Yao
    Citation: Breast Cancer Research 2024 26:1
  4. Allostatic load (AL) reflects the collective load of chronic stress during lifetime. Previous studies have shown that higher AL is associated with poor clinical outcomes among breast cancer patients. However, ...

    Authors: Yufan Guan, Jie Shen, Juan Lu, Bernard F. Fuemmeler, Lisa S. Shock and Hua Zhao
    Citation: Breast Cancer Research 2023 25:155
  5. The role of HER2 amplification level in predicting the effectiveness of HER2-directed therapies has been established. However, its association with survival outcomes in advanced HER2-positive breast cancer tre...

    Authors: Jeongmin Seo, Jiwon Koh, Dae-Won Lee, Jinyong Kim, Han Suk Ryu, Kyung-Hun Lee, Tae-Yong Kim and Seock-Ah Im
    Citation: Breast Cancer Research 2023 25:154
  6. Invasive lobular breast carcinomas (ILC) have different histological features compared to non-special type carcinomas (NST), but the effect of histological subtypes on survival is controversial. In this study,...

    Authors: Davut Dayan, Stefan Lukac, Brigitte Rack, Florian Ebner, Visnja Fink, Elena Leinert, Kristina Veselinovic, Sabine Schütze, Ziad El Taie, Wolfgang Janni and Thomas W. P. Friedl
    Citation: Breast Cancer Research 2023 25:153
  7. The homologous recombination (HR) repair pathway for DNA damage, particularly the BRCA1 and BRCA2 genes, has become a target for cancer therapy, with poly ADP-ribose polymerase (PARP) inhibitors showing significa...

    Authors: Han-Fang Cheng, Yi-Fang Tsai, Chun-Yu Liu, Chih-Yi Hsu, Pei-Ju Lien, Yen-Shu Lin, Ta-Chung Chao, Jiun-I. Lai, Chin-Jung Feng, Yen-Jen Chen, Bo-Fang Chen, Jen-Hwey Chiu, Ling-Ming Tseng and Chi-Cheng Huang
    Citation: Breast Cancer Research 2023 25:152
  8. Triple-negative breast cancer (TNBC) represents the most challenging subtype of breast cancer. Studies have implicated an upregulation of lipid synthesis pathways in the initiation and progression of TNBC. Tar...

    Authors: Pan Hu, Peiyi Zhou, Tieyun Sun, Dingkang Liu, Jun Yin and Lubin Liu
    Citation: Breast Cancer Research 2023 25:151
  9. Epidemiologic data on insecticide exposures and breast cancer risk are inconclusive and mostly from high-income countries. Using data from 1071 invasive pathologically confirmed breast cancer cases and 2096 co...

    Authors: Naomie Olivos, Jim E. Banta, Rhonda Spencer-Hwang, Daniel Ansong, Laura E. Beane Freeman, Joe-Nat Clegg-Lamptey, Beatrice Wiafe-Addai, Lawrence Edusei, Ernest Adjei, Nicholas Titiloye, Florence Dedey, Francis Aitpillah, Joseph Oppong, Verna Vanderpuye, Ernest Osei-Bonsu, Thomas U. Ahearn…
    Citation: Breast Cancer Research 2023 25:150
  10. Based on the molecular expression of cancer cells, molecular subtypes of breast cancer have been applied to classify patients for predicting clinical outcomes and prognosis. However, further evidence is needed...

    Authors: Shih-Kai Hung, Hsuan-Ju Yang, Moon-Sing Lee, Dai-Wei Liu, Liang-Cheng Chen, Chia-Hui Chew, Chun-Hung Lin, Cheng-Hung Lee, Szu-Chin Li, Chung-Lin Hong, Chih-Chia Yu, Ben-Hui Yu, Feng-Chun Hsu, Wen-Yen Chiou and Hon-Yi Lin
    Citation: Breast Cancer Research 2023 25:149
  11. Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype and leads to the poorest patient outcomes despite surgery and chemotherapy treatment. Exploring new molecular mechanisms of TNB...

    Authors: Zheqiong Tan, Pragney Deme, Keerti Boyapati, Britt S. R. Claes, Annet A. M. Duivenvoorden, Ron M. A. Heeren, Caitlin M. Tressler, Norman James Haughey and Kristine Glunde
    Citation: Breast Cancer Research 2023 25:148
  12. Women with dense breasts have an increased risk of breast cancer. However, breast density is measured with variability, which may reduce the reliability and accuracy of its association with breast cancer risk....

    Authors: Emma C. Atakpa, Diana S. M. Buist, Erin J. Aiello Bowles, Jack Cuzick and Adam R. Brentnall
    Citation: Breast Cancer Research 2023 25:147
  13. In breast cancer, the advent of anti-HER2 therapies has made HER2+ tumors a highly relevant subgroup. However, the exact characteristics which prohibit clinical response to anti-HER2 therapies and drive diseas...

    Authors: Noortje Verschoor, Marcel Smid, Agnes Jager, Stefan Sleijfer, Saskia M. Wilting and John W. M. Martens
    Citation: Breast Cancer Research 2023 25:145
  14. Breast cancer stem cells (BCSCs) are resistant to standard therapies, facilitate tumor dissemination, and contribute to relapse and progression. Super-enhancers are regulators of stemness, and BET proteins, wh...

    Authors: Deeksha Sharma, Cody G. Hager, Li Shang, Lam Tran, Yongyou Zhu, Aihui Ma, Brian Magnuson, Matthew W. Lesko, Max S. Wicha and Monika L. Burness
    Citation: Breast Cancer Research 2023 25:144
  15. As in most solid cancers, the emergence of cells with oncogenic mutations in the mammary epithelium alters the tissue homeostasis. Some soluble factors, such as TGFβ, potently modify the behavior of healthy st...

    Authors: Héctor Franco-Valls, Elsa Tusquets-Uxó, Laura Sala, Maria Val, Raúl Peña, Alessandra Iaconcig, Álvaro Villarino, Martín Jiménez-Arriola, Pere Massó, Juan L. Trincado, Eduardo Eyras, Andrés F. Muro, Jorge Otero, Antonio García de Herreros and Josep Baulida
    Citation: Breast Cancer Research 2023 25:143
  16. Invasive breast cancer patients are increasingly being treated with neoadjuvant chemotherapy; however, only a fraction of the patients respond to it completely. To prevent overtreatment, there is an urgent nee...

    Authors: Witali Aswolinskiy, Enrico Munari, Hugo M. Horlings, Lennart Mulder, Giuseppe Bogina, Joyce Sanders, Yat-Hee Liu, Alexandra W. van den Belt-Dusebout, Leslie Tessier, Maschenka Balkenhol, Michelle Stegeman, Jeffrey Hoven, Jelle Wesseling, Jeroen van der Laak, Esther H. Lips and Francesco Ciompi
    Citation: Breast Cancer Research 2023 25:142
  17. Window-of-opportunity (WOO) studies provide insights into the clinical activity of new drugs in breast cancer.

    Authors: Mario Campone, François-Clément Bidard, Patrick Neven, Lei Wang, Bin Ling, Yvonne Dong, Gautier Paux, Christina Herold and Ugo De Giorgi
    Citation: Breast Cancer Research 2023 25:141
  18. Considering the recent advancements in the treatment of breast cancer with low expression of human epidermal growth factor receptor 2 (HER2), we aimed to examine inter-laboratory variability in the assessment ...

    Authors: Kåre Nielsen, Michael Sode, Maj-Britt Jensen, Tobias Berg, Ann Knoop, Bent Ejlertsen and Anne-Vibeke Lænkholm
    Citation: Breast Cancer Research 2023 25:139
  19. To investigate combined MRI and 18F-FDG PET for assessing breast tumor metabolism/perfusion mismatch and predicting pathological response and recurrence-free survival (RFS) in women treated for breast cancer.

    Authors: Anum S. Kazerouni, Lanell M. Peterson, Isaac Jenkins, Alena Novakova-Jiresova, Hannah M. Linden, Julie R. Gralow, David M. Hockenbery, David A. Mankoff, Peggy L. Porter, Savannah C. Partridge and Jennifer M. Specht
    Citation: Breast Cancer Research 2023 25:138
  20. Despite a 40% reduction in breast cancer mortality over the last 30 years, not all groups have benefited equally from these gains. A consistent link between later stage of diagnosis and disparities in breast c...

    Authors: Jessica L. Webster, Neal D. Goldstein, Jennifer P. Rowland, Catherine M. Tuite and Scott D. Siegel
    Citation: Breast Cancer Research 2023 25:137
  21. Exposure to cytotoxic chemotherapy treatment may alter DNA methylation (DNAm) in breast cancer patients.

    Authors: Peh Joo Ho, Alexis Jiaying Khng, Benita Kiat-Tee Tan, Geok Hoon Lim, Su-Ming Tan, Veronique Kiak Mien Tan, Ryan Shea Ying Cong Tan, Elaine Hsuen Lim, Philip Tsau-Choong Iau, Ying Jia Chew, Yi Ying Lim, Mikael Hartman, Ern Yu Tan and Jingmei Li
    Citation: Breast Cancer Research 2023 25:136
  22. This study aimed to develop a novel combined immune score (CIS)-based model assessing prognosis in triple-negative breast cancer (TNBC).

    Authors: Ji Eun Choi, Jae Seok Lee, Min-Sun Jin, Ilias P. Nikas, Kwangsoo Kim, Sunah Yang, Soo Young Park, Jiwon Koh, Sohyeon Yang, Seock-Ah Im and Han Suk Ryu
    Citation: Breast Cancer Research 2023 25:134
  23. Authors: María C. Díaz Flaqué, Natalia M. Galigniana, Wendy Béguelin, Rocío Vicario, Cecilia J. Proietti, Rosalía Cordo Russo, Martín A. Rivas, Mercedes Tkach, Pablo Guzmán, Juan C. Roa, Esteban Maronna, Viviana Pineda, Sergio Muñoz, María Florencia Mercogliano, Eduardo H. Charreau, Patricio Yankilevich…
    Citation: Breast Cancer Research 2023 25:133
  24. Several studies have indicated that magnetic resonance imaging radiomics can predict survival in patients with breast cancer, but the potential biological underpinning remains indistinct. Herein, we aim to dev...

    Authors: Yunfang Yu, Wei Ren, Zifan He, Yongjian Chen, Yujie Tan, Luhui Mao, Wenhao Ouyang, Nian Lu, Jie Ouyang, Kai Chen, Chenchen Li, Rong Zhang, Zhuo Wu, Fengxi Su, Zehua Wang, Qiugen Hu…
    Citation: Breast Cancer Research 2023 25:132
  25. Mammary physiology is distinguished in containing adult stem/progenitor cells that are actively amending the breast tissue throughout the reproductive lifespan of women. Despite their importance in both mammar...

    Authors: Hakim Bouamar, Larry Esteban Broome, Kate Ida Lathrop, Ismail Jatoi, Andrew Jacob Brenner, Alia Nazarullah, Karla Moncada Gorena, Michael Garcia, Yidong Chen, Virginia Kaklamani and Lu-Zhe Sun
    Citation: Breast Cancer Research 2023 25:131
  26. Body fatness is a dynamic exposure throughout life. To provide more insight into the association between body mass index (BMI) and postmenopausal breast cancer, we aimed to examine the age at onset, duration, ...

    Authors: Marit Busund, Giske Ursin, Eiliv Lund, Tom Wilsgaard and Charlotta Rylander
    Citation: Breast Cancer Research 2023 25:130
  27. SND1 participates in tumorigenesis, tumour invasion and metastasis in different cancers. Previous studies have shown that SND1 can promote the invasion and migration of breast cancer cells. Triple-negative bre...

    Authors: Huibian Zhang, Min Gao, Wenying Zhao and Lin Yu
    Citation: Breast Cancer Research 2023 25:129
  28. Gremlin-1 (GREM1) and Gremlin-2 (GREM2) are bone morphogenetic protein antagonists that play important roles in organogenesis, tissue differentiation, and tissue homeostasis. Although GREM1 has been reported t...

    Authors: Jiwoo Jung, Na Hui Kim, Minji Kwon, Jayeon Park, Dayeon Lim, Youjin Kim, World Gil, Ye Hwang Cheong and Sin-Aye Park
    Citation: Breast Cancer Research 2023 25:128
  29. Mammogram risk scores based on texture and density defined by different brightness thresholds are associated with breast cancer risk differently and could reveal distinct information about breast cancer risk. ...

    Authors: Zhoufeng Ye, Tuong L. Nguyen, Gillian S. Dite, Robert J. MacInnis, Daniel F. Schmidt, Enes Makalic, Osamah M. Al-Qershi, Minh Bui, Vivienne F. C. Esser, James G. Dowty, Ho N. Trinh, Christopher F. Evans, Maxine Tan, Joohon Sung, Mark A. Jenkins, Graham G. Giles…
    Citation: Breast Cancer Research 2023 25:127
  30. Breast cancer metastasis is a complex, multi-step process, with high cellular heterogeneity between primary and metastatic breast cancer, and more complex interactions between metastatic cancer cells and other...

    Authors: Shikun Zhu, Mi Zhang, Xuexue Liu, Qing Luo, Jiahong Zhou, Miao Song, Jia Feng and Jinbo Liu
    Citation: Breast Cancer Research 2023 25:126
  31. An elevated number of circulating neutrophils is a poor prognostic factor for breast cancer, where evidence of bone marrow cancer-dependent priming is found. However, how early this priming is detectable remai...

    Authors: Anisha Ramessur, Bana Ambasager, Iker Valle Aramburu, Freddie Peakman, Kelly Gleason, Christoph Lehmann, Venizelos Papayannopoulos, Raoul Charles Coombes and Ilaria Malanchi
    Citation: Breast Cancer Research 2023 25:125
  32. Breast cancer (BC) is the most common malignant disease in female patients worldwide. In HER-2+ BC patients, trastuzumab therapy is associated with a better prognosis. However, many HER-2+ BC patients experien...

    Authors: Cuiwei Liu, Chong Lu, Lamu Yixi, Jiaxing Hong, Fang Dong, Shengnan Ruan, Ting Hu and Xiangwang Zhao
    Citation: Breast Cancer Research 2023 25:124
  33. Immunohistochemical (IHC) PD-L1 expression is commonly employed as predictive biomarker for checkpoint inhibitors in triple-negative breast cancer (TNBC). However, IHC evaluation methods are non-uniform and fu...

    Authors: Gudbjörg Sigurjonsdottir, Tommaso De Marchi, Anna Ehinger, Johan Hartman, Ana Bosch, Johan Staaf, Fredrika Killander and Emma Niméus
    Citation: Breast Cancer Research 2023 25:123
  34. High mammographic breast density (MBD) is a strong risk factor for breast cancer development, but the biological mechanisms underlying MBD are unclear. Lipids play important roles in cell differentiation, and ...

    Authors: Kayla R. Getz, Myung Sik Jeon, Chongliang Luo, Jingqin Luo and Adetunji T. Toriola
    Citation: Breast Cancer Research 2023 25:121
  35. Breast cancer is a complex and heterogeneous disease with distinct subtypes and molecular profiles corresponding to different clinical outcomes. Mouse models of breast cancer are widely used, but their relevan...

    Authors: Carson D. Broeker, Mylena M. O. Ortiz, Michael S. Murillo and Eran R. Andrechek
    Citation: Breast Cancer Research 2023 25:120
  36. Triple negative breast cancer (TNBC) is a particularly aggressive and difficult-to-treat subtype of breast cancer that requires the development of novel therapeutic strategies. To pave the way for such develop...

    Authors: Katharina Jonas, Felix Prinz, Manuela Ferracin, Katarina Krajina, Barbara Pasculli, Alexander Deutsch, Tobias Madl, Beate Rinner, Ondrej Slaby, Christiane Klec and Martin Pichler
    Citation: Breast Cancer Research 2023 25:119
  37. Advanced glycation end products (AGEs) are reactive metabolites intrinsically linked with modern dietary patterns. Processed foods, and those high in sugar, protein and fat, often contain high levels of AGEs. ...

    Authors: Bradley A. Krisanits, Reid Schuster, Jaime Randise, Lourdes M. Nogueira, Jackson T. Lane, Gowtami A. Panguluri, Hong Li, Kristi Helke, Maria C. Cuitiño, Christopher Koivisto, Laura Spruill, Michael C. Ostrowski, Steven M. Anderson, David P. Turner and Victoria J. Findlay
    Citation: Breast Cancer Research 2023 25:118
  38. Despite major improvements in treatment of HER2-positive metastatic breast cancer (MBC), only few patients achieve complete remission and remain progression free for a prolonged time. The tumor immune microenv...

    Authors: Tessa G. Steenbruggen, Denise M. Wolf, Michael J. Campbell, Joyce Sanders, Sten Cornelissen, Bram Thijssen, Roberto A. Salgado, Christina Yau, Nick O-Grady, Amrita Basu, Rajith Bhaskaran, Lorenza Mittempergher, Gillian L. Hirst, Jean-Philippe Coppe, Marleen Kok, Gabe S. Sonke…
    Citation: Breast Cancer Research 2023 25:117
  39. The diagnostic accuracy of digital breast tomosynthesis (DBT) and digital mammography (DM) in breast cancer screening may vary per breast density subgroup. The purpose of this study was to evaluate which women...

    Authors: Jakob Olinder, Kristin Johnson, Anna Åkesson, Daniel Förnvik and Sophia Zackrisson
    Citation: Breast Cancer Research 2023 25:116
  40. B7 homology 4 (B7-H4), a potential target for cancer therapy, has been demonstrated to inhibit T cell cytotoxicity in the early stages of breast cancer. However, B7-H4 manipulating breast tumor immune microenv...

    Authors: Linlin Zhou, Jichun Wu, Mei Ruan, Yonglei Xiao, Hailin Lan, Qiongwen Wu, Chen-Wei Yu and Qiuyu Zhang
    Citation: Breast Cancer Research 2023 25:115
  41. About 20% of breast cancers in humans are basal-like, a subtype that is often triple-negative and difficult to treat. An effective translational model for basal-like breast cancer is currently lacking and urge...

    Authors: Joshua Watson, Tianfang Wang, Kun-Lin Ho, Yuan Feng, Tanakamol Mahawan, Kevin K. Dobbin and Shaying Zhao
    Citation: Breast Cancer Research 2023 25:114
  42. Women from socioeconomically deprived areas have lower breast cancer (BC) incidence rates for screen-detected oestrogen receptor (ER) + tumours and higher mortality for select tumour subtypes. We aimed to dete...

    Authors: Hayley M. Dunlop, Linda J. Williams, Peter S. Hall, Matthew Barber, Christine Dodds and Jonine D. Figueroa
    Citation: Breast Cancer Research 2023 25:106
  43. although being central for the biology and druggability of hormone-receptor positive, HER2 negative metastatic breast cancer (MBC), ESR1 and PIK3CA mutations are simplistically dichotomized as mutated or wild ...

    Authors: Lorenzo Gerratana, Andrew A. Davis, Marko Velimirovic, Katherine Clifton, Whitney L. Hensing, Ami N. Shah, Charles S. Dai, Carolina Reduzzi, Paolo D’Amico, Firas Wehbe, Arielle Medford, Seth A. Wander, William J. Gradishar, Amir Behdad, Fabio Puglisi, Cynthia X. Ma…
    Citation: Breast Cancer Research 2023 25:112
  44. Latin American and Hispanic women are less likely to develop breast cancer (BC) than women of European descent. Observational studies have found an inverse relationship between the individual proportion of Nat...

    Authors: Linda Zollner, Diana Torres, Ignacio Briceno, Michael Gilbert, Gabriela Torres-Mejía, Joe Dennis, Manjeet K. Bolla, Qin Wang, Ute Hamann and Justo Lorenzo Bermejo
    Citation: Breast Cancer Research 2023 25:111
  45. Gene expression (GEX) signatures in breast cancer provide prognostic information, but little is known about their predictive value for tamoxifen treatment. We examined the tamoxifen-predictive value and progno...

    Authors: Christine Lundgren, Julia Tutzauer, Sarah E. Church, Olle Stål, Maria Ekholm, Carina Forsare, Bo Nordenskjöld, Mårten Fernö, Pär-Ola Bendahl and Lisa Rydén
    Citation: Breast Cancer Research 2023 25:110

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