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  1. Research article

    A 3D in vitro model of the human breast duct: a method to unravel myoepithelial-luminal interactions in the progression of breast cancer

    3D modelling fulfils a critical role in research, allowing for complex cell behaviour and interactions to be studied in physiomimetic conditions. With tissue banks becoming established for a number of cancers,...

    Edward P. Carter, James A. Gopsill, Jennifer. J. Gomm, J. Louise Jones and Richard P. Grose

    Breast Cancer Research 2017 19:50

    Published on: 21 April 2017

  2. Erratum

    Erratum to: HDAC6 activity is a non-oncogene addiction hub for inflammatory breast cancers

    Preeti Putcha, Jiyang Yu, Ruth Rodriguez-Barrueco, Laura Saucedo-Cuevas, Patricia Villagrasa, Eva Murga-Penas, Steven N. Quayle, Min Yang, Veronica Castro, David Llobet-Navas, Daniel Birnbaum, Pascal Finetti, Wendy A. Woodward, François Bertucci, Mary L. Alpaugh, Andrea Califano…

    Breast Cancer Research 2017 19:49

    Published on: 19 April 2017

    The original article was published in Breast Cancer Research 2015 17:149

  3. Research article

    Efficacy and safety of everolimus in combination with trastuzumab and paclitaxel in Asian patients with HER2+ advanced breast cancer in BOLERO-1

    The current exploratory analysis was performed to evaluate the efficacy and safety of everolimus for treatment of human epidermal growth factor receptor 2-positive (HER2+) advanced breast cancer in the Asian s...

    Masakazu Toi, Zhimin Shao, Sara Hurvitz, Ling-Ming Tseng, Qingyuan Zhang, Kunwei Shen, Donggeng Liu, Jifeng Feng, Binghe Xu, Xiaojia Wang, Keun Seok Lee, Ting Ying Ng, Antonia Ridolfi, Florence Noel-baron, Francois Ringeisen and Zefei Jiang

    Breast Cancer Research 2017 19:47

    Published on: 11 April 2017

  4. Research article

    Overexpression of syndecan-1, MUC-1, and putative stem cell markers in breast cancer leptomeningeal metastasis: a cerebrospinal fluid flow cytometry study

    Cancer is a mosaic of tumor cell subpopulations, where only a minority is responsible for disease recurrence and cancer invasiveness. We focused on one of the most aggressive circulating tumor cells (CTCs) whi...

    Iole Cordone, Serena Masi, Valentina Summa, Mariantonia Carosi, Antonello Vidiri, Alessandra Fabi, Alessia Pasquale, Laura Conti, Immacolata Rosito, Carmine Maria Carapella, Veronica Villani and Andrea Pace

    Breast Cancer Research 2017 19:46

    Published on: 11 April 2017

  5. Research article

    Association between air pollution and mammographic breast density in the Breast Cancer Surveilance Consortium

    Mammographic breast density is a well-established strong risk factor for breast cancer. The environmental contributors to geographic variation in breast density in urban and rural areas are poorly understood. ...

    Lusine Yaghjyan, Robert Arao, Cole Brokamp, Ellen S. O’Meara, Brian L. Sprague, Gabriela Ghita and Patrick Ryan

    Breast Cancer Research 2017 19:36

    Published on: 6 April 2017

  6. Research article

    Endocrine therapy initiation, discontinuation and adherence and breast imaging among 21-gene recurrence score assay-eligible women under age 65

    Aside from chemotherapy utilization, limited data are available on the relationship between gene expression profiling (GEP) testing and breast cancer care. We assessed the relationship between GEP testing and ...

    Suzanne C. O’Neill, Claudine Isaacs, Filipa Lynce, Deena Mary Atieh Graham, Calvin Chao, Vanessa B. Sheppard, Yingjun Zhou, Chunfu Liu, Nandini Selvam, Marc D. Schwartz and Arnold L. Potosky

    Breast Cancer Research 2017 19:45

    Published on: 31 March 2017

  7. Research article

    Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome

    Breast cancer is a heterogeneous disease at the clinical and molecular level. In this study we integrate classifications extracted from five different molecular levels in order to identify integrated subtypes.

    Miriam Ragle Aure, Valeria Vitelli, Sandra Jernström, Surendra Kumar, Marit Krohn, Eldri U. Due, Tonje Husby Haukaas, Suvi-Katri Leivonen, Hans Kristian Moen Vollan, Torben Lüders, Einar Rødland, Charles J. Vaske, Wei Zhao, Elen K. Møller, Silje Nord, Guro F. Giskeødegård…

    Breast Cancer Research 2017 19:44

    Published on: 29 March 2017

  8. Research article

    Glucocorticoids induce production of reactive oxygen species/reactive nitrogen species and DNA damage through an iNOS mediated pathway in breast cancer

    Psychological stress increases the circulating levels of the stress hormones cortisol and norepinephrine (NE). Chronic exposure to elevated stress hormones has been linked to a reduced response to chemotherapy...

    Renée L. Flaherty, Matthew Owen, Aidan Fagan-Murphy, Haya Intabli, David Healy, Anika Patel, Marcus C. Allen, Bhavik A. Patel and Melanie S. Flint

    Breast Cancer Research 2017 19:35

    Published on: 24 March 2017

  9. Review

    Decision making for breast cancer prevention among women at elevated risk

    Several medical management approaches have been shown to be effective in preventing breast cancer and detecting it early among women at elevated risk: 1) prophylactic mastectomy; 2) prophylactic oophorectomy; ...

    Tasleem J. Padamsee, Celia E. Wills, Lisa D. Yee and Electra D. Paskett

    Breast Cancer Research 2017 19:34

    Published on: 24 March 2017

  10. Research article

    Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function

    Normal myoepithelial cells (MECs) play an important tumour-suppressor role in the breast but display an altered phenotype in ductal carcinoma in situ (DCIS), gaining tumour-promoter functions. Matrix metallopr...

    Muge Sarper, Michael D. Allen, Jenny Gomm, Linda Haywood, Julie Decock, Sally Thirkettle, Ahsen Ustaoglu, Shah-Jalal Sarker, John Marshall, Dylan R. Edwards and J. Louise Jones

    Breast Cancer Research 2017 19:33

    Published on: 23 March 2017

  11. Research article

    Detecting gene signature activation in breast cancer in an absolute, single-patient manner

    The ability to reliably identify the state (activated, repressed, or latent) of any molecular process in the tumor of a patient from an individual whole-genome gene expression profile obtained from microarray ...

    E. R. Paquet, R. Lesurf, A. Tofigh, V. Dumeaux and M. T. Hallett

    Breast Cancer Research 2017 19:32

    Published on: 21 March 2017

    The Erratum to this article has been published in Breast Cancer Research 2017 19:48

  12. Research article

    Nighttime eating and breast cancer among Chinese women in Hong Kong

    A novel line of research suggests that eating at nighttime may have several metabolic consequences that are highly relevant to breast cancer. We investigated the association between nighttime eating habits aft...

    Mengjie Li, Lap Ah Tse, Wing-cheong Chan, Chi-hei Kwok, Siu-lan Leung, Cherry Wu, Wai-cho Yu, Priscilla Ming-yi Lee, Koon-ho Tsang, Sze-hong Law, Roel Vermeulen, Fangyi Gu, Neil E. Caporaso, Ignatius Tak-sun Yu, Feng Wang and Xiaohong Rose Yang

    Breast Cancer Research 2017 19:31

    Published on: 17 March 2017

  13. Research article

    Increased genomic burden of germline copy number variants is associated with early onset breast cancer: Australian breast cancer family registry

    Women with breast cancer who have multiple affected relatives are more likely to have inherited genetic risk factors for the disease. All the currently known genetic risk factors for breast cancer account for ...

    Logan C. Walker, John F. Pearson, George A. R. Wiggins, Graham G. Giles, John L. Hopper and Melissa C. Southey

    Breast Cancer Research 2017 19:30

    Published on: 16 March 2017

  14. Research article

    A clinical model for identifying the short-term risk of breast cancer

    Most mammography screening programs are not individualized. To efficiently screen for breast cancer, the individual risk of the disease should be determined. We describe a model that could be used at most mamm...

    Mikael Eriksson, Kamila Czene, Yudi Pawitan, Karin Leifland, Hatef Darabi and Per Hall

    Breast Cancer Research 2017 19:29

    Published on: 14 March 2017

  15. Research article

    Anthropometric measures and serum estrogen metabolism in postmenopausal women: the Women’s Health Initiative Observational Study

    Several anthropometric measures have been associated with hormone-related cancers. However, it is unknown whether estrogen metabolism plays an important role in these relationships. We examined whether measure...

    Hannah Oh, Sally B. Coburn, Charles E. Matthews, Roni T. Falk, Erin S. LeBlanc, Jean Wactawski-Wende, Joshua Sampson, Ruth M. Pfeiffer, Louise A. Brinton, Nicolas Wentzensen, Garnet L. Anderson, JoAnn E. Manson, Chu Chen, Oleg Zaslavsky, Xia Xu and Britton Trabert

    Breast Cancer Research 2017 19:28

    Published on: 11 March 2017

  16. Research article

    The method of detection of ductal carcinoma in situ has no therapeutic implications: results of a population-based cohort study

    Population screening with mammography has resulted in increased detection of ductal carcinoma in situ (DCIS). The aim of this population-based cohort study was to assess whether the method of detection should ...

    Lotte E. Elshof, Michael Schaapveld, Emiel J. Rutgers, Marjanka K. Schmidt, Linda de Munck, Flora E. van Leeuwen and Jelle Wesseling

    Breast Cancer Research 2017 19:26

    Published on: 9 March 2017

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