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  1. Research article

    Age-related terminal duct lobular unit involution in benign tissues from Chinese breast cancer patients with luminal and triple-negative tumors

    Terminal duct lobular unit (TDLU) involution is a physiological process of breast tissue aging characterized by a reduction in the epithelial component. In studies of women with benign breast disease, research...

    Changyuan Guo, Hyuna Sung, Shan Zheng, Jennifer Guida, Erni Li, Jing Li, Nan Hu, Joseph Deng, Jonine D. Figueroa, Mark E. Sherman, Gretchen L. Gierach, Ning Lu and Xiaohong R. Yang

    Breast Cancer Research 2017 19:61

    Published on: 25 May 2017

  2. Research article

    Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models

    Mutations in the estrogen receptor alpha (ERα) 1 gene (ESR1) are frequently detected in ER+ metastatic breast cancer, and there is increasing evidence that these mutations confer endocrine resistance in breast ca...

    Amir Bahreini, Zheqi Li, Peilu Wang, Kevin M. Levine, Nilgun Tasdemir, Lan Cao, Hazel M. Weir, Shannon L. Puhalla, Nancy E. Davidson, Andrew M. Stern, David Chu, Ben Ho Park, Adrian V. Lee and Steffi Oesterreich

    Breast Cancer Research 2017 19:60

    Published on: 23 May 2017

  3. Research article

    Rapid evaporative ionisation mass spectrometry of electrosurgical vapours for the identification of breast pathology: towards an intelligent knife for breast cancer surgery

    Re-operation for positive resection margins following breast-conserving surgery occurs frequently (average = 20–25%), is cost-inefficient, and leads to physical and psychological morbidity. Current margin asse...

    Edward R. St John, Julia Balog, James S. McKenzie, Merja Rossi, April Covington, Laura Muirhead, Zsolt Bodai, Francesca Rosini, Abigail V. M. Speller, Sami Shousha, Rathi Ramakrishnan, Ara Darzi, Zoltan Takats and Daniel R. Leff

    Breast Cancer Research 2017 19:59

    Published on: 23 May 2017

  4. Research article

    An updated PREDICT breast cancer prognostication and treatment benefit prediction model with independent validation

    PREDICT is a breast cancer prognostic and treatment benefit model implemented online. The overall fit of the model has been good in multiple independent case series, but PREDICT has been shown to underestimate...

    Francisco J. Candido dos Reis, Gordon C. Wishart, Ed M. Dicks, David Greenberg, Jem Rashbass, Marjanka K. Schmidt, Alexandra J. van den Broek, Ian O. Ellis, Andrew Green, Emad Rakha, Tom Maishman, Diana M. Eccles and Paul D. P. Pharoah

    Breast Cancer Research 2017 19:58

    Published on: 22 May 2017

  5. Research article

    Intratumoral and peritumoral radiomics for the pretreatment prediction of pathological complete response to neoadjuvant chemotherapy based on breast DCE-MRI

    In this study, we evaluated the ability of radiomic textural analysis of intratumoral and peritumoral regions on pretreatment breast cancer dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to pre...

    Nathaniel M. Braman, Maryam Etesami, Prateek Prasanna, Christina Dubchuk, Hannah Gilmore, Pallavi Tiwari, Donna Pletcha and Anant Madabhushi

    Breast Cancer Research 2017 19:57

    Published on: 18 May 2017

  6. Research article

    Pathomimetic avatars reveal divergent roles of microenvironment in invasive transition of ductal carcinoma in situ

    The breast tumor microenvironment regulates progression of ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC). However, it is unclear how interactions between breast epithelial and stromal cell...

    Mansoureh Sameni, Dora Cavallo-Medved, Omar E. Franco, Anita Chalasani, Kyungmin Ji, Neha Aggarwal, Arulselvi Anbalagan, Xuequn Chen, Raymond R. Mattingly, Simon W. Hayward and Bonnie F. Sloane

    Breast Cancer Research 2017 19:56

    Published on: 15 May 2017

  7. Research article

    An international reproducibility study validating quantitative determination of ERBB2, ESR1, PGR, and MKI67 mRNA in breast cancer using MammaTyper®

    Accurate determination of the predictive markers human epidermal growth factor receptor 2 (HER2/ERBB2), estrogen receptor (ER/ESR1), progesterone receptor (PgR/PGR), and marker of proliferation Ki67 (MKI67) is in...

    Zsuzsanna Varga, Annette Lebeau, Hong Bu, Arndt Hartmann, Frederique Penault-Llorca, Elena Guerini-Rocco, Peter Schraml, Fraser Symmans, Robert Stoehr, Xiaodong Teng, Andreas Turzynski, Reinhard von Wasielewski, Claudia Gürtler, Mark Laible, Kornelia Schlombs, Heikki Joensuu…

    Breast Cancer Research 2017 19:55

    Published on: 11 May 2017

  8. Research article

    A phase-I study of lapatinib in combination with foretinib, a c-MET, AXL and vascular endothelial growth factor receptor inhibitor, in human epidermal growth factor receptor 2 (HER-2)-positive metastatic breast cancer

    The mechanisms of resistance to anti-human epidermal growth factor receptor 2 (HER 2) therapies are unclear but may include the tyrosine-protein kinase Met (c-Met), vascular endothelial growth factor (VEGF) an...

    Stephen K. Chia, Susan L. Ellard, Mihaela Mates, Stephen Welch, Catalin Mihalcioiu, Wilson H. Miller, Karen Gelmon, Caroline Lohrisch, Vikaash Kumar, Sara Taylor, Linda Hagerman, Rachel Goodwin, Tao Wang, Shingo Sakashita, Ming S. Tsao, Elizabeth Eisenhauer…

    Breast Cancer Research 2017 19:54

    Published on: 2 May 2017

  9. Research article

    TIMELESS contributes to the progression of breast cancer through activation of MYC

    Breast cancer is the most common malignancy and the leading cause of cancer death among women. TIMELESS (TIM), a circadian rhythm regulator, has been recently implicated in the progression of human cancer. How...

    Limin Chi, Yujiao Zou, Ling Qin, Weifeng Ma, Yanyan Hao, Yao Tang, Rongcheng Luo and Ziqing Wu

    Breast Cancer Research 2017 19:53

    Published on: 2 May 2017

  10. Research article

    Regular and low-dose aspirin, other non-steroidal anti-inflammatory medications and prospective risk of HER2-defined breast cancer: the California Teachers Study

    Regular users of aspirin may have reduced risk of breast cancer. Few studies have addressed whether risk reduction pertains to specific breast cancer subtypes defined jointly by hormone receptor (estrogen and ...

    Christina A. Clarke, Alison J. Canchola, Lisa M. Moy, Susan L. Neuhausen, Nadia T. Chung, James V. Lacey and Leslie Bernstein

    Breast Cancer Research 2017 19:52

    Published on: 1 May 2017

  11. Research article

    Cooperation of neurotrophin receptor TrkB and Her2 in breast cancer cells facilitates brain metastases

    Patients with primary breast cancer that is positive for human epidermal growth factor receptor 2 (Her2+) have a high risk of developing metastases in the brain. Despite gains with systemic control of Her2+ di...

    Cecilia Choy, Khairul I. Ansari, Josh Neman, Sarah Hsu, Matthew J. Duenas, Hubert Li, Nagarajan Vaidehi and Rahul Jandial

    Breast Cancer Research 2017 19:51

    Published on: 26 April 2017

  12. Research article

    A 3D in vitro model of the human breast duct: a method to unravel myoepithelial-luminal interactions in the progression of breast cancer

    3D modelling fulfils a critical role in research, allowing for complex cell behaviour and interactions to be studied in physiomimetic conditions. With tissue banks becoming established for a number of cancers,...

    Edward P. Carter, James A. Gopsill, Jennifer. J. Gomm, J. Louise Jones and Richard P. Grose

    Breast Cancer Research 2017 19:50

    Published on: 21 April 2017

  13. Erratum

    Erratum to: HDAC6 activity is a non-oncogene addiction hub for inflammatory breast cancers

    Preeti Putcha, Jiyang Yu, Ruth Rodriguez-Barrueco, Laura Saucedo-Cuevas, Patricia Villagrasa, Eva Murga-Penas, Steven N. Quayle, Min Yang, Veronica Castro, David Llobet-Navas, Daniel Birnbaum, Pascal Finetti, Wendy A. Woodward, François Bertucci, Mary L. Alpaugh, Andrea Califano…

    Breast Cancer Research 2017 19:49

    Published on: 19 April 2017

    The original article was published in Breast Cancer Research 2015 17:149

  14. Research article

    Efficacy and safety of everolimus in combination with trastuzumab and paclitaxel in Asian patients with HER2+ advanced breast cancer in BOLERO-1

    The current exploratory analysis was performed to evaluate the efficacy and safety of everolimus for treatment of human epidermal growth factor receptor 2-positive (HER2+) advanced breast cancer in the Asian s...

    Masakazu Toi, Zhimin Shao, Sara Hurvitz, Ling-Ming Tseng, Qingyuan Zhang, Kunwei Shen, Donggeng Liu, Jifeng Feng, Binghe Xu, Xiaojia Wang, Keun Seok Lee, Ting Ying Ng, Antonia Ridolfi, Florence Noel-baron, Francois Ringeisen and Zefei Jiang

    Breast Cancer Research 2017 19:47

    Published on: 11 April 2017

  15. Research article

    Overexpression of syndecan-1, MUC-1, and putative stem cell markers in breast cancer leptomeningeal metastasis: a cerebrospinal fluid flow cytometry study

    Cancer is a mosaic of tumor cell subpopulations, where only a minority is responsible for disease recurrence and cancer invasiveness. We focused on one of the most aggressive circulating tumor cells (CTCs) whi...

    Iole Cordone, Serena Masi, Valentina Summa, Mariantonia Carosi, Antonello Vidiri, Alessandra Fabi, Alessia Pasquale, Laura Conti, Immacolata Rosito, Carmine Maria Carapella, Veronica Villani and Andrea Pace

    Breast Cancer Research 2017 19:46

    Published on: 11 April 2017

  16. Research article

    Association between air pollution and mammographic breast density in the Breast Cancer Surveilance Consortium

    Mammographic breast density is a well-established strong risk factor for breast cancer. The environmental contributors to geographic variation in breast density in urban and rural areas are poorly understood. ...

    Lusine Yaghjyan, Robert Arao, Cole Brokamp, Ellen S. O’Meara, Brian L. Sprague, Gabriela Ghita and Patrick Ryan

    Breast Cancer Research 2017 19:36

    Published on: 6 April 2017

  17. Research article

    Endocrine therapy initiation, discontinuation and adherence and breast imaging among 21-gene recurrence score assay-eligible women under age 65

    Aside from chemotherapy utilization, limited data are available on the relationship between gene expression profiling (GEP) testing and breast cancer care. We assessed the relationship between GEP testing and ...

    Suzanne C. O’Neill, Claudine Isaacs, Filipa Lynce, Deena Mary Atieh Graham, Calvin Chao, Vanessa B. Sheppard, Yingjun Zhou, Chunfu Liu, Nandini Selvam, Marc D. Schwartz and Arnold L. Potosky

    Breast Cancer Research 2017 19:45

    Published on: 31 March 2017

  18. Research article

    Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome

    Breast cancer is a heterogeneous disease at the clinical and molecular level. In this study we integrate classifications extracted from five different molecular levels in order to identify integrated subtypes.

    Miriam Ragle Aure, Valeria Vitelli, Sandra Jernström, Surendra Kumar, Marit Krohn, Eldri U. Due, Tonje Husby Haukaas, Suvi-Katri Leivonen, Hans Kristian Moen Vollan, Torben Lüders, Einar Rødland, Charles J. Vaske, Wei Zhao, Elen K. Møller, Silje Nord, Guro F. Giskeødegård…

    Breast Cancer Research 2017 19:44

    Published on: 29 March 2017

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