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  1. Research article

    Glucocorticoids induce production of reactive oxygen species/reactive nitrogen species and DNA damage through an iNOS mediated pathway in breast cancer

    Psychological stress increases the circulating levels of the stress hormones cortisol and norepinephrine (NE). Chronic exposure to elevated stress hormones has been linked to a reduced response to chemotherapy...

    Renée L. Flaherty, Matthew Owen, Aidan Fagan-Murphy, Haya Intabli, David Healy, Anika Patel, Marcus C. Allen, Bhavik A. Patel and Melanie S. Flint

    Breast Cancer Research 2017 19:35

    Published on: 24 March 2017

  2. Review

    Decision making for breast cancer prevention among women at elevated risk

    Several medical management approaches have been shown to be effective in preventing breast cancer and detecting it early among women at elevated risk: 1) prophylactic mastectomy; 2) prophylactic oophorectomy; ...

    Tasleem J. Padamsee, Celia E. Wills, Lisa D. Yee and Electra D. Paskett

    Breast Cancer Research 2017 19:34

    Published on: 24 March 2017

  3. Research article

    Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function

    Normal myoepithelial cells (MECs) play an important tumour-suppressor role in the breast but display an altered phenotype in ductal carcinoma in situ (DCIS), gaining tumour-promoter functions. Matrix metallopr...

    Muge Sarper, Michael D. Allen, Jenny Gomm, Linda Haywood, Julie Decock, Sally Thirkettle, Ahsen Ustaoglu, Shah-Jalal Sarker, John Marshall, Dylan R. Edwards and J. Louise Jones

    Breast Cancer Research 2017 19:33

    Published on: 23 March 2017

  4. Research article

    Detecting gene signature activation in breast cancer in an absolute, single-patient manner

    The ability to reliably identify the state (activated, repressed, or latent) of any molecular process in the tumor of a patient from an individual whole-genome gene expression profile obtained from microarray ...

    E. R. Paquet, R. Lesurf, A. Tofigh, V. Dumeaux and M. T. Hallett

    Breast Cancer Research 2017 19:32

    Published on: 21 March 2017

    The Erratum to this article has been published in Breast Cancer Research 2017 19:48

  5. Research article

    Nighttime eating and breast cancer among Chinese women in Hong Kong

    A novel line of research suggests that eating at nighttime may have several metabolic consequences that are highly relevant to breast cancer. We investigated the association between nighttime eating habits aft...

    Mengjie Li, Lap Ah Tse, Wing-cheong Chan, Chi-hei Kwok, Siu-lan Leung, Cherry Wu, Wai-cho Yu, Priscilla Ming-yi Lee, Koon-ho Tsang, Sze-hong Law, Roel Vermeulen, Fangyi Gu, Neil E. Caporaso, Ignatius Tak-sun Yu, Feng Wang and Xiaohong Rose Yang

    Breast Cancer Research 2017 19:31

    Published on: 17 March 2017

  6. Research article

    Increased genomic burden of germline copy number variants is associated with early onset breast cancer: Australian breast cancer family registry

    Women with breast cancer who have multiple affected relatives are more likely to have inherited genetic risk factors for the disease. All the currently known genetic risk factors for breast cancer account for ...

    Logan C. Walker, John F. Pearson, George A. R. Wiggins, Graham G. Giles, John L. Hopper and Melissa C. Southey

    Breast Cancer Research 2017 19:30

    Published on: 16 March 2017

  7. Research article

    A clinical model for identifying the short-term risk of breast cancer

    Most mammography screening programs are not individualized. To efficiently screen for breast cancer, the individual risk of the disease should be determined. We describe a model that could be used at most mamm...

    Mikael Eriksson, Kamila Czene, Yudi Pawitan, Karin Leifland, Hatef Darabi and Per Hall

    Breast Cancer Research 2017 19:29

    Published on: 14 March 2017

  8. Research article

    Anthropometric measures and serum estrogen metabolism in postmenopausal women: the Women’s Health Initiative Observational Study

    Several anthropometric measures have been associated with hormone-related cancers. However, it is unknown whether estrogen metabolism plays an important role in these relationships. We examined whether measure...

    Hannah Oh, Sally B. Coburn, Charles E. Matthews, Roni T. Falk, Erin S. LeBlanc, Jean Wactawski-Wende, Joshua Sampson, Ruth M. Pfeiffer, Louise A. Brinton, Nicolas Wentzensen, Garnet L. Anderson, JoAnn E. Manson, Chu Chen, Oleg Zaslavsky, Xia Xu and Britton Trabert

    Breast Cancer Research 2017 19:28

    Published on: 11 March 2017

  9. Research article

    The method of detection of ductal carcinoma in situ has no therapeutic implications: results of a population-based cohort study

    Population screening with mammography has resulted in increased detection of ductal carcinoma in situ (DCIS). The aim of this population-based cohort study was to assess whether the method of detection should ...

    Lotte E. Elshof, Michael Schaapveld, Emiel J. Rutgers, Marjanka K. Schmidt, Linda de Munck, Flora E. van Leeuwen and Jelle Wesseling

    Breast Cancer Research 2017 19:26

    Published on: 9 March 2017

  10. Research article

    DCYTB is a predictor of outcome in breast cancer that functions via iron-independent mechanisms

    Duodenal cytochrome b (DCYTB) is a ferrireductase that functions together with divalent metal transporter 1 (DMT1) to mediate dietary iron reduction and uptake in the duodenum. DCYTB is also a member of a 16-g...

    David J. Lemler, Miranda L. Lynch, Lia Tesfay, Zhiyong Deng, Bibbin T. Paul, Xiaohong Wang, Poornima Hegde, David H. Manz, Suzy V. Torti and Frank M. Torti

    Breast Cancer Research 2017 19:25

    Published on: 7 March 2017

  11. Short report

    Circulating gamma-glutamyl transferase and development of specific breast cancer subtypes: findings from the Apolipoprotein Mortality Risk (AMORIS) cohort

    Different etiological pathways may precede development of specific breast cancer subtypes and impact prevention or treatment strategies. We investigated the association between gamma-glutamyl transferase (GGT)...

    Lydia Shackshaft, Mieke Van Hemelrijck, Hans Garmo, Håkan Malmström, Mats Lambe, Niklas Hammar, Göran Walldius, Ingmar Jungner and Wahyu Wulaningsih

    Breast Cancer Research 2017 19:22

    Published on: 6 March 2017

  12. Research article

    Zoledronic acid alters hematopoiesis and generates breast tumor-suppressive bone marrow cells

    The bone-targeting agent zoledronic acid (ZOL) increases breast cancer survival in subsets of patients, but the underlying reasons for this protective effect are unknown. ZOL modulates the activity of osteocla...

    Jessalyn M. Ubellacker, Marie-Therese Haider, Molly J. DeCristo, Gloria Allocca, Nicola J. Brown, Daniel P. Silver, Ingunn Holen and Sandra S. McAllister

    Breast Cancer Research 2017 19:23

    Published on: 6 March 2017

  13. Research article

    EZH2 protein expression in normal breast epithelium and risk of breast cancer: results from the Nurses’ Health Studies

    Enhancer of zeste homolog 2 (EZH2) is a polycomb-group protein that is involved in stem cell renewal and carcinogenesis. In breast cancer, increased EZH2 expression is associated with aggressiveness and has be...

    Francisco Beca, Kevin Kensler, Benjamin Glass, Stuart J. Schnitt, Rulla M. Tamimi and Andrew H. Beck

    Breast Cancer Research 2017 19:21

    Published on: 2 March 2017

  14. Research article

    Immune profiles of elderly breast cancer patients are altered by chemotherapy and relate to clinical frailty

    Effective therapeutic management of elderly patients with cancer, on an individual basis, remains a clinical challenge. Here, we identify novel biomarkers to assess elderly patients (≥70 years of age) with bre...

    Jithendra Kini Bailur, Graham Pawelec, Sigrid Hatse, Barbara Brouwers, Ann Smeets, Patrick Neven, Annouschka Laenen, Hans Wildiers and Christopher Shipp

    Breast Cancer Research 2017 19:20

    Published on: 28 February 2017

  15. Research article

    Modification of the association between recreational physical activity and survival after breast cancer by promoter methylation in breast cancer-related genes

    Mechanisms underlying the inverse association between physical activity and survival after breast cancer are unresolved, but DNA methylation may play a role. We hypothesized that promoter methylation of breast...

    Lauren E. McCullough, Jia Chen, Yoon Hee Cho, Nikhil K. Khankari, Patrick T. Bradshaw, Alexandra J. White, Susan L. Teitelbaum, Mary Beth Terry, Alfred I. Neugut, Hanina Hibshoosh, Regina M. Santella and Marilie D. Gammon

    Breast Cancer Research 2017 19:19

    Published on: 21 February 2017

  16. Research article

    Phase II, randomized, placebo-controlled study of dovitinib in combination with fulvestrant in postmenopausal patients with HR+, HER2 breast cancer that had progressed during or after prior endocrine therapy

    Overexpression of fibroblast growth factor receptor 1 (FGFR1), found in ≤8% of hormone receptor–positive (HR+), human epidermal growth factor receptor 2–negative (HER2) breast cancer cases, is correlated with de...

    Antonino Musolino, Mario Campone, Patrick Neven, Neelima Denduluri, Carlos H. Barrios, Javier Cortes, Kimberly Blackwell, Hatem Soliman, Zsuzsanna Kahan, Hervé Bonnefoi, Matthew Squires, Yong Zhang, Stephanie Deudon, Michael M. Shi and Fabrice André

    Breast Cancer Research 2017 19:18

    Published on: 10 February 2017

  17. Erratum

    Erratum to: Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer

    Zhi Hu, Jian-Hua Mao, Christina Curtis, Ge Huang, Shenda Gu, Laura Heiser, Marc E. Lenburg, James E. Korkola, Nora Bayani, Shamith Samarajiwa, Jose A. Seoane, Mark A. Dane, Amanda Esch, Heidi S. Feiler, Nicholas J. Wang, Mary Ann Hardwicke…

    Breast Cancer Research 2017 19:17

    Published on: 9 February 2017

    The original article was published in Breast Cancer Research 2016 18:70

  18. Research article

    Biomarker analysis of the NeoSphere study: pertuzumab, trastuzumab, and docetaxel versus trastuzumab plus docetaxel, pertuzumab plus trastuzumab, or pertuzumab plus docetaxel for the neoadjuvant treatment of HER2-positive breast cancer

    NeoSphere showed significantly higher pathologic complete response (pCR) with neoadjuvant pertuzumab, trastuzumab, and docetaxel compared with trastuzumab plus docetaxel, pertuzumab plus trastuzumab, or pertuz...

    Giampaolo Bianchini, Astrid Kiermaier, Giulia Valeria Bianchi, Young-Hyuck Im, Tadeusz Pienkowski, Mei-Ching Liu, Ling-Ming Tseng, Mitch Dowsett, Lila Zabaglo, Sarah Kirk, Tania Szado, Jennifer Eng-Wong, Lukas C. Amler, Pinuccia Valagussa and Luca Gianni

    Breast Cancer Research 2017 19:16

    Published on: 9 February 2017

  19. Research article

    Thymosin beta 10 is a key regulator of tumorigenesis and metastasis and a novel serum marker in breast cancer

    Thymosin beta 10 (TMSB10) has been demonstrated to be involved in the malignant process of many cancers. The purpose of this study was to determine the biological roles and clinical significance of TMSB10 in b...

    Xin Zhang, Dong Ren, Ling Guo, Lan Wang, Shu Wu, Chuyong Lin, Liping Ye, Jinrong Zhu, Jun Li, Libing Song, Huanxin Lin and Zhenyu He

    Breast Cancer Research 2017 19:15

    Published on: 8 February 2017

  20. Research article

    Childhood body size and pubertal timing in relation to adult mammographic density phenotype

    An earlier age at onset of breast development and longer time between pubertal stages has been implicated in breast cancer risk. It is not clear whether associations of breast cancer risk with puberty or predi...

    Minouk J. Schoemaker, Michael E. Jones, Steven Allen, Jean Hoare, Alan Ashworth, Mitch Dowsett and Anthony J. Swerdlow

    Breast Cancer Research 2017 19:13

    Published on: 7 February 2017

  21. Research article

    Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production

    The insulin-like growth factor 1 (IGF1) signaling axis plays a major role in tumorigenesis. In a previous experiment, we chronically treated mice with several agonists of the IGF1 receptor (IGF1R). We found th...

    Bas ter Braak, Christine L. Siezen, Joo S. Lee, Pooja Rao, Charlotte Voorhoeve, Eytan Ruppin, Jan Willem van der Laan and Bob van de Water

    Breast Cancer Research 2017 19:14

    Published on: 7 February 2017

  22. Research article

    Non-invasive optical spectroscopic monitoring of breast development during puberty

    Tanner staging (TS), a five-stage classification indicating no breast tissue (TS1) to full breast development (TS5), is used both in health research and clinical care to assess the onset of breast development ...

    Lothar Lilge, Mary Beth Terry, Jane Walter, Dushanthi Pinnaduwage, Gord Glendon, Danielle Hanna, Mai-Liis Tammemagi, Angela Bradbury, Saundra Buys, Mary Daly, Esther M. John, Julia A. Knight and Irene L. Andrulis

    Breast Cancer Research 2017 19:12

    Published on: 6 February 2017

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