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  1. Research article

    PIK3CA mutations are common in lobular carcinoma in situ, but are not a biomarker of progression

    Lobular carcinoma in situ (LCIS) is a non-invasive breast lesion that is typically found incidentally on biopsy and is often associated with invasive lobular carcinoma (ILC). LCIS is considered by some to be a ri...

    Vandna Shah, Salpie Nowinski, Dina Levi, Irek Shinomiya, Narda Kebaier Ep Chaabouni, Cheryl Gillett, Anita Grigoriadis, Trevor A. Graham, Rebecca Roylance, Michael A. Simpson, Sarah E. Pinder and Elinor J. Sawyer

    Breast Cancer Research 2017 19:7

    Published on: 17 January 2017

  2. Research article

    Reproductive factors and the risk of triple-negative breast cancer in white women and African-American women: a pooled analysis

    Early age at menarche, nulliparity, late age at first completed pregnancy, and never having breastfed, are established breast cancer risk factors. However, among breast cancer subtypes, it remains unclear whet...

    Huiyan Ma, Giske Ursin, Xinxin Xu, Eunjung Lee, Kayo Togawa, Lei Duan, Yani Lu, Kathleen E. Malone, Polly A. Marchbanks, Jill A. McDonald, Michael S. Simon, Suzanne G. Folger, Jane Sullivan-Halley, Dennis M. Deapen, Michael F. Press and Leslie Bernstein

    Breast Cancer Research 2017 19:6

    Published on: 13 January 2017

  3. Research article

    CCL2-driven inflammation increases mammary gland stromal density and cancer susceptibility in a transgenic mouse model

    Macrophages play diverse roles in mammary gland development and breast cancer. CC-chemokine ligand 2 (CCL2) is an inflammatory cytokine that recruits macrophages to sites of injury. Although CCL2 has been dete...

    Xuan Sun, Danielle J. Glynn, Leigh J. Hodson, Cecilia Huo, Kara Britt, Erik W. Thompson, Lucy Woolford, Andreas Evdokiou, Jeffrey W. Pollard, Sarah A. Robertson and Wendy V. Ingman

    Breast Cancer Research 2017 19:4

    Published on: 11 January 2017

  4. Research article

    18FDG-PET/CT for predicting the outcome in ER+/HER2- breast cancer patients: comparison of clinicopathological parameters and PET image-derived indices including tumor texture analysis

    This study investigated the value of some clinicopathological parameters and 18 F-fluorodeoxyglucose-positron emission tomography/computed tomography (18FDG-PET/CT) indices, including textural features, to predic...

    David Groheux, Antoine Martineau, Luis Teixeira, Marc Espié, Patricia de Cremoux, Philippe Bertheau, Pascal Merlet and Charles Lemarignier

    Breast Cancer Research 2017 19:3

    Published on: 5 January 2017

  5. Research article

    Prognostic role of neutrophil-to-lymphocyte ratio in breast cancer: a systematic review and meta-analysis

    The presence of a high neutrophil-to-lymphocyte ratio (NLR) has been associated with increased mortality in several malignancies. Here, we quantify the effect of NLR on survival in patients with breast cancer,...

    Josee-Lyne Ethier, Danielle Desautels, Arnoud Templeton, Prakesh S. Shah and Eitan Amir

    Breast Cancer Research 2017 19:2

    Published on: 5 January 2017

  6. Erratum

    Erratum to: Mammographic texture and risk of breast cancer by tumor type and estrogen receptor status

    Serghei Malkov, John A. Shepherd, Christopher G. Scott, Rulla M. Tamimi, Lin Ma, Kimberly A. Bertrand, Fergus Couch, Matthew R. Jensen, Amir P. Mahmoudzadeh, Bo Fan, Aaron Norman, Kathleen R. Brandt, V. Shane Pankratz, Celine M. Vachon and Karla Kerlikowske

    Breast Cancer Research 2017 19:1

    Published on: 4 January 2017

    The original article was published in Breast Cancer Research 2016 18:122

  7. Research article

    Lifetime body size and estrogen-receptor-positive breast cancer risk in the California Teachers Study cohort

    Obesity is a public health epidemic and an important breast cancer risk factor. The relationship between interrelated body measurements is complex and most studies fail to account for this complexity. We ident...

    Pamela L. Horn-Ross, Alison J. Canchola, Leslie Bernstein, Susan L. Neuhausen, David O. Nelson and Peggy Reynolds

    Breast Cancer Research 2016 18:132

    Published on: 21 December 2016

  8. Research article

    The glucose transporter GLUT1 is required for ErbB2-induced mammary tumorigenesis

    Altered tumor cell metabolism is an emerging hallmark of cancer; however, the precise role for glucose in tumor initiation is not known. GLUT1 (SLC2A1) is expressed in breast cancer cells and is likely responsibl...

    Elizabeth A. Wellberg, Stevi Johnson, Jessica Finlay-Schultz, Andrew S. Lewis, Kristina L. Terrell, Carol A. Sartorius, E. Dale Abel, William J. Muller and Steven M. Anderson

    Breast Cancer Research 2016 18:131

    Published on: 20 December 2016

  9. Research article

    Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems

    Inter-women and intra-women comparisons of mammographic density (MD) are needed in research, clinical and screening applications; however, MD measurements are influenced by mammography modality (screen film/di...

    Anya Burton, Graham Byrnes, Jennifer Stone, Rulla M. Tamimi, John Heine, Celine Vachon, Vahit Ozmen, Ana Pereira, Maria Luisa Garmendia, Christopher Scott, John H. Hipwell, Caroline Dickens, Joachim Schüz, Mustafa Erkin Aribal, Kimberly Bertrand, Ava Kwong…

    Breast Cancer Research 2016 18:130

    Published on: 19 December 2016

  10. Research article

    Circulating cell-free DNA-based epigenetic assay can detect early breast cancer

    Circulating cell-free DNA (cfDNA) has recently been recognized as a resource for biomarkers of cancer progression, treatment response, and drug resistance. However, few have demonstrated the usefulness of cfDN...

    Natsue Uehiro, Fumiaki Sato, Fengling Pu, Sunao Tanaka, Masahiro Kawashima, Kosuke Kawaguchi, Masahiro Sugimoto, Shigehira Saji and Masakazu Toi

    Breast Cancer Research 2016 18:129

    Published on: 19 December 2016

  11. Research article

    Involution of breast tissue and mammographic density

    Mammographic density decreases and involution of breast tissue increases with age; both are thought to be risk factors for breast cancer. The current study investigated the relationship between involution or h...

    Gertraud Maskarinec, Dan Ju, David Horio, Lenora W. M. Loo and Brenda Y. Hernandez

    Breast Cancer Research 2016 18:128

    Published on: 15 December 2016

  12. Research article

    Imaging the mammary gland and mammary tumours in 3D: optical tissue clearing and immunofluorescence methods

    High-resolution 3D imaging of intact tissue facilitates cellular and subcellular analyses of complex structures within their native environment. However, difficulties associated with immunolabelling and imagin...

    Bethan Lloyd-Lewis, Felicity M. Davis, Olivia B. Harris, Jessica R. Hitchcock, Filipe C. Lourenco, Mathias Pasche and Christine J. Watson

    Breast Cancer Research 2016 18:127

    Published on: 13 December 2016

  13. Research article

    Safety and efficacy of vinorelbine in combination with pertuzumab and trastuzumab for first-line treatment of patients with HER2-positive locally advanced or metastatic breast cancer: VELVET Cohort 1 final results

    Pertuzumab, trastuzumab, and docetaxel is standard of care for first-line treatment of HER2-positive metastatic breast cancer (MBC). However, alternative chemotherapy partners are required to align with patien...

    Edith A. Perez, José Manuel López-Vega, Thierry Petit, Claudio Zamagni, Valerie Easton, Julia Kamber, Eleonora Restuccia and Michael Andersson

    Breast Cancer Research 2016 18:126

    Published on: 13 December 2016

  14. Research article

    Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry

    Approximately 100 common breast cancer susceptibility alleles have been identified in genome-wide association studies (GWAS). The utility of these variants in breast cancer risk prediction models has not been ...

    Wanqing Wen, Xiao-ou Shu, Xingyi Guo, Qiuyin Cai, Jirong Long, Manjeet K. Bolla, Kyriaki Michailidou, Joe Dennis, Qin Wang, Yu-Tang Gao, Ying Zheng, Alison M. Dunning, Montserrat García-Closas, Paul Brennan, Shou-Tung Chen, Ji-Yeob Choi…

    Breast Cancer Research 2016 18:124

    Published on: 8 December 2016

  15. Research article

    MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib

    Metastatic disease is largely resistant to therapy and accounts for almost all cancer deaths. Myeloid cell leukemia-1 (MCL-1) is an important regulator of cell survival and chemo-resistance in a wide range of ...

    Adelaide I. J. Young, Andrew M. K. Law, Lesley Castillo, Sabrina Chong, Hayley D. Cullen, Martin Koehler, Sebastian Herzog, Tilman Brummer, Erinna F. Lee, Walter D. Fairlie, Morghan C. Lucas, David Herrmann, Amr Allam, Paul Timpson, D. Neil Watkins, Ewan K. A. Millar…

    Breast Cancer Research 2016 18:125

    Published on: 8 December 2016

  16. Research article

    The AF-1-deficient estrogen receptor ERα46 isoform is frequently expressed in human breast tumors

    To date, all studies conducted on breast cancer diagnosis have focused on the expression of the full-length 66-kDa estrogen receptor alpha (ERα66). However, much less attention has been paid to a shorter 46-kD...

    Elodie Chantalat, Frédéric Boudou, Henrik Laurell, Gaëlle Palierne, René Houtman, Diana Melchers, Philippe Rochaix, Thomas Filleron, Alexandre Stella, Odile Burlet-Schiltz, Anne Brouchet, Gilles Flouriot, Raphaël Métivier, Jean-François Arnal, Coralie Fontaine and Françoise Lenfant

    Breast Cancer Research 2016 18:123

    Published on: 7 December 2016

  17. Research article

    Mammographic texture and risk of breast cancer by tumor type and estrogen receptor status

    Several studies have shown that mammographic texture features are associated with breast cancer risk independent of the contribution of breast density. Thus, texture features may provide novel information for ...

    Serghei Malkov, John A. Shepherd, Christopher G. Scott, Rulla M. Tamimi, Lin Ma, Kimberly A. Bertrand, Fergus Couch, Matthew R. Jensen, Amir P. Mahmoudzadeh, Bo Fan, Aaron Norman, Kathleen R. Brandt, V. Shane Pankratz, Celine M. Vachon and Karla Kerlikowske

    Breast Cancer Research 2016 18:122

    Published on: 6 December 2016

    The Erratum to this article has been published in Breast Cancer Research 2017 19:1

  18. Research article

    An immune stratification reveals a subset of PD-1/LAG-3 double-positive triple-negative breast cancers

    Stromal tumor-infiltrating lymphocytes (TILs) are a robust prognostic factor in triple-negative breast cancer (TNBC). However, the clinical significance of TILs may be influenced by the complex landscape of th...

    Giulia Bottai, Carlotta Raschioni, Agnese Losurdo, Luca Di Tommaso, Corrado Tinterri, Rosalba Torrisi, Jorge S. Reis-Filho, Massimo Roncalli, Christos Sotiriou, Armando Santoro, Alberto Mantovani, Sherene Loi and Libero Santarpia

    Breast Cancer Research 2016 18:121

    Published on: 3 December 2016

  19. Research article

    High mammographic breast density predicts locoregional recurrence after modified radical mastectomy for invasive breast cancer: a case-control study

    We aimed to evaluate the influence of mammographic breast density at diagnosis on the risk of cancer recurrence and survival outcomes in patients with invasive breast cancer after modified radical mastectomy.

    Yu-Sen Huang, Jenny Ling-Yu Chen, Chiun-Sheng Huang, Sung-Hsin Kuo, Fu-Shan Jaw, Yao-Hui Tseng, Wei-Chun Ko and Yeun-Chung Chang

    Breast Cancer Research 2016 18:120

    Published on: 1 December 2016

  20. Research article

    Propranolol and survival from breast cancer: a pooled analysis of European breast cancer cohorts

    Preclinical studies have demonstrated that propranolol inhibits several pathways involved in breast cancer progression and metastasis. We investigated whether breast cancer patients who used propranolol, or ot...

    Chris R. Cardwell, Anton Pottegård, Evelien Vaes, Hans Garmo, Liam J. Murray, Chris Brown, Pauline A. J. Vissers, Michael O’Rorke, Kala Visvanathan, Deirdre Cronin-Fenton, Harlinde De Schutter, Mats Lambe, Des G. Powe, Myrthe P. P. van Herk-Sukel, Anna Gavin, Søren Friis…

    Breast Cancer Research 2016 18:119

    Published on: 1 December 2016

  21. Letter

    The complexities and caveats of lineage tracing in the mammary gland

    Lineage tracing is increasingly being utilised to probe different cell types that exist within the mammary gland. Whilst this technique is powerful for tracking cells in vivo and dissecting the roles of differ...

    Anne C. Rios, Nai Yang Fu, Joseph Cursons, Geoffrey J. Lindeman and Jane E. Visvader

    Breast Cancer Research 2016 18:116

    Published on: 25 November 2016

  22. Meeting report

    Complexity galore: 3D cultures, biomechanics and systems medicine at the eighth ENBDC workshop “Methods in Mammary Gland Development and Cancer”

    The ENBDC workshop “Methods in Mammary Gland Development and Cancer” is an established international forum to showcase the latest technical advances in the field. The eighth meeting focused on emerging concept...

    Bethan Lloyd-Lewis, Anoeska A. A. van de Moosdijk, Mohamed Bentires-Alj, Robert B. Clarke and Renée van Amerongen

    Breast Cancer Research 2016 18:115

    Published on: 25 November 2016

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